Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.
Polymyalgia rheumatica is an inflammatory disease with muscle pain and stiffness, especially in the shoulders, affecting mostly older adults beyond age of 65.
In animal study of inflammatory diseases induced by injection of LPS, application of green tea bioactive polyphenols EGCG improved antioxidant status of the host and decreased production of inflammatory factors, including PMR through its antioxidant properties.
Further analysis suggested that application of EGCG reduced symptoms of inflammation such as pain, tension, stiffness, swelling of the infectious site without affecting the function of immune system in protection against micro organisms invasion through inhibiting over-expression of tumor necrosis alpha(TNF-α) involved in systematic inflammatory response to acute phase of infection.
The bioactive compound also inhibited reactive oxygen species (ROS) in stimulated production of inflammatory cytokines through free radicals chain reactions in facilitated inflammation and precipitated skeletal muscle dysfunction and degradation by infiltrating immune cells to induce direct injury to muscle tissue or activating catabolic signaling.
In fact, over production of ROS increased continuously expression of mitochondria, NAD(P)H oxidases, xanthine oxidoreductases, and nitric oxide synthases caused imbalance of the free radicals and antioxidant ratio, in orchestrated oxidative stress to muscle cells..
Further evaluation suggested that green tea EGCG reduced expression of interleukin 6 (IL-6), with function in response to infections and tissue injuries.
Long term over production of IL 6 due to the duo factors as a pro and anti inflammatory protein may increase high-level concentrations of serum amyloid A (SAA), which has been found to induce serious complication of several chronic inflammatory diseases through generated and deposited amyloid A amyloidosis into the extracellular space in an abnormal, insoluble, fibrillar form,
Moreover, EGCG also attenuated levels of nuclear factor kappa B (NF-κB) in regulated innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses through activation of tumor necrosis factor alpha (TNF-α) in promoted muscle wasting, leading to muscle atrophy in induction of pain and stiffness and swelling.
Importantly, application of green tea EGCG enhanced the natural antioxidant enzymes in the host such as glutathione, an antioxidant enzyme produced naturally found in every cell and tissue of the body.
These actions together with antioxidant initiated by injection of green tea EGCG stimulated cell regeneration, preserved the muscle cells and tissues and prevented muscle tension to precipitate polymyalgia arthritis.
Deficiency of glutathione levels was found to associate to the early development of Polymyalgia Arthritis in facilitated symptoms of pain, stiffness, achiness, fatigue and fever.
Differentiation of the above was supported by conventional medicine corticosteroids, a powerful anti-inflammatory drugs with function to target pro inflammation cytokines in relieved stiffness and pain in patients with polymyalgia arthritis.
Taken together, Green tea and its bioactive polyphenols EGCG may ne considered as a function food for alleviating symptoms, risk, progression and treatment of polymyalgia arthritis (rheumatica). However, ingestion green tea supplements should be taken with extreme care as acute liver toxicity has been reported in several medical literature.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Epigallocatechin-3-gallate attenuates lipopolysaccharide-induced mastitis in rats via suppressing MAPK mediated inflammatory responses and oxidative stress by Chen J1, Xu J1, Li J1, Du L1, Chen T2, Liu P1, Peng S1, Wang M1, Song H3.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)