Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of fibromyalgia (FM) caused by stress, some scientists suggested.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in US alone.
In the review of the existed literature in relation between fibromyalgia in a somatic response to psychological stress, researchers found that patients with the chronic illness display a numbers of abnormalities in neuroendocrine function as a result of chronic stress.
Further analysis of the hormone expression of HPA axis and sympatho-adrenal system HPA axis, along with the sympatho-adrenal system in response to the chronic stress, researchers found that HPA axis is underactive in fibromyalgia due to insufficient hypothalamus in stimulated the release corticotrophin-releasing hormone (CRH) in activation of cortisol secretion from the adrenals, caused by chronic stress.
Levels of corticotrophin-releasing hormone (CRH) was activated by the responsiveness of DHEA.
These result reaffirmed the consistent with a central abnormality of the HPA axis in fibromyalgia, resulting from the undersecretion of CRH by the hypothalamus.
In a randomized cross-over design study, 18 students (nine male and nine female) participated in three experimental trials on different days at intervals of seven days conducted by the University of Shizuoka, researchers showed that according to the differentiated Saliva collected before beverage intake and after performing the mental stress load tasks, green tea treatment group exerted a significant improvement of Total Mood Disturbance (TMD) score on the Profile of Mood States (POMS).
Moreover, green tea treatment group ameliorated the increased salivary CgA concentration levels in response to psychological and physical stress after mental stress load tasks.
Both green and white tea demonstrated a strong effect in improve performance on an arithmetic task in compared to warm water treated group.
However, green tea ingestion exerted lesser anti stress activity in compared to the consumption of white tea group.
The above differentiation were supported by the study of theanine, an amino acid in green tea anti-stress effects on animals and humans activity in examined three types of green teas, theanine-rich "Gyokuro", standard "Sencha", and Sencha with lowered caffeine (low-caffeine green tea) in mice model, conducted by the joint study lead by the joint University of Shizuoka.
According to the study, application of green tea showed a strong effect in normalized adrenal dysfunction (hyper-adrenal DHEA production), induced by chronic stress, eluted with water at room temperature.
Interestingly, researchers after taking into account of other co founders suggested that application of caffeine and tea, polyphenol EGCG suppressed the anti-stress caused by (hyper-adrenal DHEA production in this case) effects of theanine while EGC and arginine (Arg) retained these effects.
Additionally, in the investigation of green tea phytochemical epigallocatechin-3-gallate (EGCG) in alleviating age-associated aberrations in immunity, hypothalamus-pituitary-adrenal (HPA) axis in 16 months old male Swiss albino mice, rendomized assigned to four groups of animals (n = 6 per group) given supplemented with either aqueous EGCG at 25, 50 and 100 mg/kg/animal or vehicle control for 6 weeks, scientists indicated that EGCG treatment mice during aging strengthens systemic immunity by enhancing cellular immune response and simultaneously attenuating antibody response aided by increasing adrenal DHEA production(hypo-adrenal DHEA production in this case), another indication of correlation between expression of adrenal dysfunction of development of fibromyalgia.
Green tea anti chronic stress in reduced fibromyalgia caused by adrenal dysfunction was attributed to the over all effects of all chemical constituents, including the levels of theanine, EGC, arginine (Arg) and EGCG.
The findings suggested that green tea consists a significant activity in ameliorated adrenal dysfunction caused by chronic stress, particularly, in chronic stress initiated hypo-adrenal DHEA production for precipitation of fibromyalgia.
Taken together, green tea as a whole food medicine may be considered as a function food in ameliorated early onset, progression and combined with standard medicine for treatment of fibromyalgia due to long term exposure to psychological stress. However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link by Anindya Gupta1 and Alan J Silman(PMC)
(2) Intake of green tea inhibited increase of salivary chromogranin A after mental task stress loads by Yoto A1, Murao S, Nakamura Y, Yokogoshi H.(PubMed)
(3) Anti-stress effects of drinking green tea with lowered caffeine and enriched theanine, y epigallocatechin and arginine on psychosocial stress induced adrenal hypertrophy in mice bUnno K1, Hara A2, Nakagawa A2, Iguchi K2, Ohshio M3, Morita A3, Nakamura Y4.(PubMed)
(4) Consumption of green tea epigallocatechin-3-gallate enhances systemic immune response, antioxidative capacity and HPA axis functions in aged male swiss albino mice by Sharma R1, Sharma A2, Kumari A3, Kulurkar PM2, Raj R2, Gulati A3, Padwad YS4.(PubMed)