Fennel may have a potential and therapeutic effect in reduced risk and treatment of breast cancer, some scientists suggested.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
In the evaluation of the essential oil extracted from fennel activity in human breast cancer cell line (MDA-Mb), researchers found that application of fennel extract exerted a significant effect in inhibition of the expression of cancer cell line at dose of lower than f lower than 10 μg/mL with IC50.
In other words, application of highly oxidative hydrogen peroxide in breast caner cell line may cause a significant cytotoxic effect in the cancer cell death.
These results demonstrated the correlation of increase of apoptosis with the rise in generation of reactive oxygen species in cancer cells.
Due to this potential activity, some researchers suggested that hydrogen peroxide overproduced in tumor cells can serve as a prodrug for the treatment of cancer.
However, Fennel exerted a lesser effect in inhibited cancer MCF-7 cells with nicotine induced cell migration in compared to other spices such as pepper, long pepper and ginger.
According to the result from Gas chromatographic-mass spectrometric analysis, fennel displayed a moderated antioxidant in precipitated cytotoxic activity against MCF-7 (human breast adenocarcinoma) with IC50 values between 30-210 mg L-1 in compared to cytotoxic reference compounds.
In fact, the efficacy of fennel essential oil in inhibited the breast caner proliferation and migration was attributed to the presence of lipophilic secondary metabolites and anise aldehyde, which have a potential in elevated the interference with molecular targets in cells by fennel antioxidant compounds such as anethole.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Analysis and evaluation of the antimicrobial and anticancer activities of the essential oil isolated from Foeniculum vulgare from Hamedan, Iran by Akhbari M1, Kord R1, Jafari Nodooshan S2, Hamedi S3.(PubMed)
(2) Cytotoxicity of the Essential Oil of Fennel (Foeniculum vulgare) from Tajikistan by Sharopov F1,2, Valiev A3, Satyal P4, Gulmurodov I5, Yusufi S6, Setzer WN7, Wink M8.(PubMed)
(3) Dietary spices protect against hydrogen peroxide-induced DNA damage and inhibit nicotine-induced cancer cell migration by Jayakumar R1, Kanthimathi MS.(PubMed)