Friday, 23 February 2018

Herbal Therapy: Green Tea Significantly Improved Glucose Metabolism in Prediabetics

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in improved glucose metabolism, some scientists suggested.

Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Glucose metabolism is an action of the body to convert glucose intake to energy to nourish the body tissues and organs through oxidized to carbon dioxide and water.

Long term abnormal glucose metabolism is considered as a leading cause of diabetes and diabetic complications.

Green tea extract, in the evaluation of the on carbohydrate metabolic key enzymes in control and streptozotocin high fat diet -induced diabetic rats in 30 days, demonstrated a significant activity in ameliorated the over expression of plasma glucose, glycosylated hemoglobin (HbA1c) and increase in the levels of insulin and hemoglobin.

Further analysis also found that the application exerted a profound effect in restore, in some extends, the function of altered activities of the key enzymes of carbohydrate metabolism, such as hexokinase, pyruvate kinase, lactate dehydrogenase in both diabetic and control groups.

In diabetic rats group, green tea extract strongly averted the abnormal expression of glycogen phosphorylase in liver to near normal levels.

Additionally, diabetic group after administration of green tea extract exhibited antihyperglycemic potential, obsevered through improved muscle and hepatic glycogen content.

The information findings showed green tea extract have a directed implication in attenuated abnormal glucose metabolism in compared to the effectiveness of conventional medicine metformin, a standard oral hypoglycemic drug.

Moreover, in the study to confirm the epidemiological study suggestion of improvement in glucose metabolism in diabetic mice and healthy humans upon green tea consumption, researchers found that
injection green tea in diabetic mice and streptozotocin-induced diabetic mice after 2-6 h expresses lower levels of glucose with no alternation of serum insulin level, at dose of 300 mg/kg in compared to normal control mice.

In protein differentiation, green tea extract administration decreased the serum protein level which has been associated to glucose production, minimized the increase of blood glucose levels through stmulating additional small amounts of insulin in the diabetes.  These results addressed another indication of green tea function in exerted direct influence in modulation of glucose metabolism in the tested subject.

Interestingly, in the investigation of green tea effect in glucose uptake inhibitory activity in Caco-2 cells, researchers indicated that green tea at temperature of 60 degree in Celsius significantly improved capacity of antioxidant in inhibition of glucose uptake through regulation of cell glucose metabolism.

Incredibly, temperature over 60 degree Celsius, green tea application did not increased or showed a up ward trend in the inhibitory potential, the Huazhong Agricultural University suggested.

Taken together, green tea with abundant bioactive phytochemicals may be considered as a function food in improved glucose metabolism in reduced risk of diabetes onset. People in high risk diabetes such as prediabetics may want to add 1 or 2 cups of green tea into their diet for preventive measure.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Modulatory effect of green tea extract on hepatic key enzymes of glucose metabolism in streptozotocin and high fat diet induced diabetic rats by Sundaram R1, Naresh R, Shanthi P, Sachdanandam P.(PubMed)
(2) Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans by Tsuneki H1, Ishizuka M, Terasawa M, Wu JB, Sasaoka T, Kimura I.(PubMed)
(3) Effect of steeping temperature on antioxidant and inhibitory activities of green tea extracts against α-amylase, α-glucosidase and intestinal glucose uptake by Liu S1, Ai Z2, Qu F3, Chen Y4, Ni D5.(PubMed)

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