Saturday, 24 February 2018

Herbal Therapy: Green tea and Its Polyphenols for Prevention and Treatment of Colitis

Kyle J. Norton 

Green tea may have a therapeutic and profound effect in reduced risk and treatment of colictiss, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.

Colitis is a medical condition characterized by inflammation of the inner lining of the colon as a result of infection, inflammation caused by other bowel diseases.

In the comparison of the effects of green tea extract epigallocatechin-3-gallate, EGCG and
Piper nigrum (L.) alkaloid piperine in mice colitis induced by oral administration of dextran sodium sulfate randomly assigned to a daily oral administration of 6.9 mg/kg body weight EGCG or Piper nigrum (L.) piperine (2.9 mg/kg body weight) or the combination of the both with piperine used in the combination to enhance the bioavailability of EGCG and untreated controls, researchers at the Münster University Hospital showed that mice group treated with the combination demonstrate a significant effect in reduced weight loss and improved over all survival in compared to non treatment group through inducing lesser histological damages to the colon and reduction of tissue concentrations of malondialdehyde, an indication of decreased oxidative stress.

According to neutrophils accumulation assay, application of green tea EGCG and piperine displayed a strong activity in reduced ROS expression in induction of lipid peroxidation through activation of over expression of antioxidant enzymes such as superoxide dismutase(SOD) and glutathione peroxidase(GPO).

Further examining also found that the combined ingredients induced a also reduced the production of proinflammatory cytokines.

Dr. Brückner M, after taking into account of other con-founders suggested, "the concept of anti-inflammatory properties of EGCG being generally beneficial in the DSS-model of colitis".

Interestingly, in dextran sulfate sodium (DSS)-induced mouse model of colitis, application of green tea EGCG (3.2 mg/g) as a source of drinking fluid for 3 days exerted a significant effect in ameliorated of colon shortening and spleen enlargement caused by injection of DSS and modulated the production of levels inflammatory cytokines of of interleukin 1 beta (IL-1β) and
Interleukin 6 (IL-6), which play the important roles in regulation of immune and inflammatory responses to acute and chronic infections.

Further more, green tea oral administration also decreased levels of tumor necrosis factor-α, a cell signaling protein in activated systemic inflammation and pro inflammatory cytokines in acute phase of reaction and inhibited ROS expression colonic lipid peroxides through antioxidant activity.

Moreover, the bioactive polyphenol EGCG also improved the small intestinal function in reduced leaky gut, associated to risk of increase the number of harmful compounds entering the bloodstream.

Further analysis of green tea efficacy in treatment of colitis, researchers discovered that green tea EGCG also induced weight loss through binding on the surface of the small intestine in decreased protein and lipid digestion.

In additional evaluation of green tea polyphenols (GrTP, EGCG) and sulfasalazine activity in colitis induced by injection of Dextran sodium sulfate (DSS) to cause deficiency of IL-10 in BALB/c mice, researchers at the University of Kentucky, postulated that the combined administration significantly ameliorate colonic damage and histological scores in a similar manner (GrTP vs. DSS p < 0.05; EGCG, sulfasalazine vs. DSS p < 0.01) and decrease expression of the inflammatory markers TNFα (3-fold), IL-6 (14-fold) as mentioned above.

Importantly, treated mice with both green tea polyphenols (GrTP, EGCG) and sulfasalazine also expressed a huge improvement in antioxidant capacity in inhibition of ROS in initiated chain reaction to facilitate of plagues formation and inflammation, observed by activity of bio maker lectin levels.

The information findings insisted that green tea with abundantly selective bioactive polyphenols may be considered as a functional food for prevention and treatment of colitis. However, intake of green tea supplement should be taken with exceptional care as acute liver toxicity was reported in numbers of case.

Reprint of this article is welcome with author name and link to the article intact

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Green tea polyphenol epigallocatechin-3-gallate shows therapeutic antioxidative effects in a murine model of colitis by Brückner M1, Westphal S, Domschke W, Kucharzik T, Lügering A.(PubMed)
(2) (-)-Epigallocatechin-3-gallate decreases colonic inflammation and permeability in a mouse model of colitis, but reduces macronutrient digestion and exacerbates weight loss by Bitzer ZT1, Elias RJ1, Vijay-Kumar M2, Lambert JD3,4.(PubMed)
(3) Green Tea Polyphenols and Sulfasalazine have Parallel Anti-Inflammatory Properties in ColitisModels by Oz HS1, Chen T, de Villiers WJ.(PubMed)

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