Friday, 16 February 2018

Herbal Therapy: Green Tea And Its Bioactive Polyphenols in Reduced Risk, Progression of Fibromyalgia Caused by Sleep Disturbance

Kyle J. Norton 

Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of  fibromyalgia caused by sleep disturbance, some scientists suggested.

Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.

Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in US alone.

In the study of sleep disturbance causable fibromyalgia Dr. Choy EH suggested that patients with fibromyalgia demonstrated a reduced short-wave sleep and abnormal α-rhythms, suggestive of wakefulness during non-REM (rapid eye movement) sleep in compared to the healthy individuals according observation of polysomnography.

Further more, in healthy participants, the study indicated that sleep deprivation can also cause fibromyalgia like symptoms such as myalgia, tenderness and fatigue and suggested that sleep dysfunction might be not only a consequence of pain.

These results showed a strong correlated conditions of sleep disturbance and initiation of chronic fibromyalgia if sleep disorders are left untreated for a prolonged period of time.

Moreover, according to the presentation, long time effect of sleep disturbance may influences alter the pathophysiology of the central nervous system in abnormal pain processing and central sensitization, according to observation of the neuroimaging of patients with fibromyalgia neural activation in compared to lower pressure-pain threshold in healthy age-matched and gender-matched individuals.

After taking into account to other con founders, researchers said, " improving sleep quality can reduce pain and fatigue, further supporting the hypothesis that sleep dysfunction is a pathogenic stimulus of fibromyalgia".

Green tea, bioactive polyphenols (-)-Epigallocatechin gallate (EGCG) in the evaluation of the the chick brain under an acute stressful condition in facilitated sleep disturbance, researchers found that EGCG attenuates stress behavior with special reference to gamma-aminobutyric acid (GABA), a neurotransmitter with function in sending chemical messages through the brain and the nervous system, and involving in regulating communication between brain cells in stress environment.

Deficiency of is associated to many nervous conditions, including depression, anxiety, and sleep disorders.

Application of EGCG of doses of 50, 100 and 200 microg, intracerebroventricularly exerted a profound effect in suppressed the vocalization which normally occurs during social separation stress.

This illustration truly suggested that EGCG reduced the time spent in active wakefulness and induced sleep-like behavior in a dose-dependent manner.

Further more, under influence and presence of the GABAA receptor antagonist picrotoxin but not by the GABAB receptor antagonist CGP 54626 (3-N-(1-(3,4-dichlorophenyl)ethylamino)-2-hydroxypropyl cyclohexylmethyl phosphinic acid hydrochloride), a antidote in poisoning by CNS depressants, the effect of green tea EGCG is significantly decrease in attenuated the production of hormone corticosterone release under social separation stress.

These interaction opinionated that EGCG inducted sedation and hypnosis in reduced stress hormone production in precipitated sleep distance probably though GABAA receptors in moderated an acute stress response.

Some researchers suggested that green tea improved symptoms of fibromyalgia by normalizing the levels of GABA (gamma-aminobutyric acid) when came under stress,  may have a therapeutic effect in reduced anxiety by relaxing the muscles and the brain. through increased production of dopamines, serotonin, and alpha waves within the brain in orchestrated the sleep pattern.

These improvements were associated to the interaction of the brain with chemical compounds found in green tea Caffeine and L-theanine, suggested by the author.

Taken together, the information findings suggested that green tea and its bioactive polyphenols EGCG and L-theanine may be considered as a functional food for reduced risk, progression and treatment of fibromyalgia caused by sleep disorder. However, intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Sources
(1) The role of sleep in pain and fibromyalgia by Choy EH(PubMed)
(2) (-)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain by Adachi N1, Tomonaga S, Tachibana T, Denbow DM, Furuse M.(research gate)
(3) Green Tea Health Benefits To Get You Drinking Healthy! by Abby Hannaford

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