Psoriasis is a immuno-inflammatory disease characterized by speeding up the life cycle of skin cells to induce skin cells to build up rapidly on the surface.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
In the investigation of green tea EGCG effect on BALB/c mice induced psoriasis by topically treated with imiquimod (IMQ) for 6 consecutive days, as a psoriasis mouse model, researchers found that application of green tea bioactive compound demonstrated a significant effect in improved psoriasiform dermatitis, and the skin pathological structure by inhibited the proliferating cell nuclear antigen (PCNA) which has been found in elevated levels in patient with psoriasis.
The levels of proliferating cell nuclear antigen (PCNA) considered as a bio marker and a abnormal proliferating cell pool in patient with skin cancer was also inhibited by EGCG injection
Administration of EGCG promoted caspase-14 expression which has been altered in patients with psoriasis to orchestrate epidermal differentiation in decreased in inflammatory lesions in atopic dermatitis through its function as a novel regulator of skin cell differentiation and skin barrier formation to protect the skin cell against inflammation.
Significantly, green tea also reduced infiltrations of T cells in facilitate inflammatory skin lesions caused by injection of imiquimod (IMQ).
Moreover, EGCG also ameliorated the production of malondialdehyde (MDA), an end product of lipid peroxidation in plasma obsevered by the protocol with colorimetric Diagnostic Reagent Kit an indication of over production of reactive oxygen species (ROS) in precipitated free radical chain reaction to induced oxidative stress caused by psoriasis through expression of its antioxidants and induced production of natural antioxidants in the body.
Importantly, the application of green tea compound increased percentages of CD4+ T cells in immunocytes in activated a series of local immunologically mediated stimulatory events that produce further T cell activation and appearance against triggers conversion of symptomless (PN) skin into psoriatic plaques (PP skin).
EGCG attenuates the IMQ-induced histological changes of skin) of marked hyperkeratosis, parakeratosis, modest acanthosis, elongated rete ridges, and modest dermal inflammation.... , increased parakeratosis, acanthosis and inflammatory cell infiltration (caused by IMQ)".
EGCG exerted anti-inflammatory, immune regulatory and antioxidant effects in ameliorated expression of psoriasis may also have strong implication in prevented psoriasis in induction of chronic inflammation of the joint in catalyzed psoriatic arthritis.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice by Shuangshuang Zhang,#1 Xiangdong Liu,#2 Lihong Mei,1 Hongfeng Wang,1 and Fang Fang(PMC)