fibromyalgia caused by oxidative stress, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain affecting over 10 million (3.6% of the population) people in US alone.
According to the study in review of literature of the frequency and pattern of complementary and alternative medicine (CAM) of 289(95%) patients who completed the survey (263 women and 26 men) between February 2003 and July 2003, green tea was recommended at 24% for treatment of fibromyalgia (FM).
In the investigation of the effect of green tea epigallocatechin-3-gallate (EGCG) in protection of oxidative stress to cardiac cells cultured in the conditions of control, 400 μM H2O2 exposure for 30 min with and/or without 10 to 20 μM EGCG pre-treatment, researchers at the National Tsing Hua University found that treatment of green tea in H(2)O(2) group demonstrated a significant reduction of levels of reactive oxygen species through its antioxidant and its ability in induced production of natural antioxidant presented in the cardiac cells in compared to over expression of ROS in H2O2 treatment group without injection of EGCG.
Interestingly, EGCG inhibited the ameliorated H(2)O(2) expression in increased glycolytic protein in response to the degree of oxidative stress in the culture cells and α-enolase, a key glycolytic enzyme on the surface of several cell types in contribution of impaired glycolytic activity through oxidative and nitrative stress.
Additionally, green tea EGCG also decreased levels of peroxiredoxin-4, an antioxidant with function in protection against oxidative stress by detoxifying peroxides and mitochondrial proteins with function of redox reactions of oxidative phosphorylation.
After taking into account of other con founders, researchers suggested that ingestion of green tea EGCG inhibited the damage of H(2)O(2) group through inhibition of the downstream signalling for Akt in expression glucose oxidation and cell apoptosis in cellular processes, and loss of phosphorylation of GSK-3β and cyclin D1 depletion in facilitated oxidative stress.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Use of complementary and alternative medical therapies by patients referred to a fibromyalgiatreatment program at a tertiary care center by Wahner-Roedler DL1, Elkin PL, Vincent A, Thompson JM, Oh TH, Loehrer LL, Mandrekar JN, Bauer BA.(PubMed)
(2) Oxidative stress and mitochondrial dysfunction in fibromyalgia by Cordero MD1, de Miguel M, Carmona-López I, Bonal P, Campa F, Moreno-Fernández AM(PubMed)Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)
(3) Molecular identification for epigallocatechin-3-gallate-mediated antioxidant intervention on the H2O2-induced oxidative stress in H9c2 rat cardiomyoblasts by Chen WC, Hsieh SR, Chiu CH, Hsu BD1, Liou YM.(PubMed)