Monday, 23 March 2015

The Holistic approach for Prevention, controlling and Treatment - Chinese Herbs for Upper and Middle burner causes of Candida Albicans Overgrowth

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What is Candida Albicans

Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that do not cause harmful effects, but overgrowth result in candidiasis. Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.


                                                In Traditional Chinese Medicine 

In traditional Chinese medicine, candidiasis is defined as a malfunction of the Triple Burner-related condition due to spleen and stomach disorder(401), causing excess fluid or phlegm in our system(402), weakening immune system(403)(402), leading to damp heat accumulates in the Lower, Middle and Upper Burner causes of candidiasis(401).

                                                   Cleansing TCM Herbs

Overgrowth of candida in TCM is considered as the accumulation of waste, phlegm and damp heat, toxins due to inability of spleen and stomach in digesting foods properly(401).

Chinese herbs for Upper and Middle burner disorder causes of Candida albicans overgrowth

1. Huang Lian (Rhizoma Coptidis)
Huang lian is aslo known as Canker roots, a genus of Coptis in the family Ranunculaceae, native to Asia and North America. The bitter and cool herb has been used in TCM as anti microbial(462)(463)(464)Including Candica albicans(465)(466), anti inflammatory(467)(468), antidiabetic(469)(470), anti palette coagulative(461) agents and to treat irritable bowel syndrome(471), inflammation of intestine and diarrhea(460) caused by bacterial infection by clearing heat(460)(461), drying damp(460)(461), dispersing fire and expelling toxins(460) as it promotes the functions of heart, large intestine, liver, and stomach channels(461).

2. Da Huang (Radix et Rhizoma Rhei)
Da Huang is also known as Ruhbarb, is a genus Rheum, belonging the family Polygonaceae. The bitter and cold herb has been used in TCM to treat diarrhoea(472), bowel movement(473), aging induced dementia(474), tumor(475), abdominal-distention and/or pain(476), hemorrhoidal bleeding(476) and urination burning sensation(476), bacterial infection(477) and improve blood circulation(477), by clearing damp heat(477), expelling toxins(478)(480) and invigorating blood(477) as it promotes the functions of heart, large intestine, liver, stomach channels(476). According to Advances in Viridans Streptococci Research and Treatment: 2011 Edition, da huang showed to exhibit antimicrobial activity against many strains of bacterias(479), including candida albicans(480).

3. Huang Bai (Cortex Phellodendri) 
Huang Bai is also known as Cork-tree, a genus of Phellodendra, belonging to the family Rutaceae, native to east and northeast Asia. The bitter and cold herb has been used in TCM as anti microbial(481)(482)(483), including candida albicans(484)(485), anti inflammatory(486)(487)  and anti trichomoniasis(488), to lower blood pressure(489) and blood sugar(490) by
clearing damp heat(481) in the lower burner due to bacterial infection(480), dispersing fire(480) and expeling toxins(480) as it promotes the functions of kidney and bladder channels(488).

4. Shi Gao (Herba Achilleae alpinae)
Shi Gao is also known as Gypsum, a very soft mineral composed of calcium sulfate dihydrate. The bitter, very cod and acrid herb has been used in TCM as antipyretics(492), antimicrobial(496)(497) including candida albicans(498)and to treat asthma(492), relieve pain(493)(494) and diabetes(495) by clearing and fire(499), as it promotes the functions of lung, kidney channels(500).

5. Lian Qiao (Fructus Forsythiae Suspensae)
Lian Qiao is also known as Forsythia fruit, is a genus of Forsythia, belongs to the family Oleaceae, native to Eastern Asia. The bitter, cold and slightly acrid herb has been used as spectrum antibiotic(501)(502)(503), antioxidant(502)(503), inflammatory(504)(505) agents and to  treat asthma(506), lower fever(507), cholesterol(509) and to protect liver(510) by clearing heat and toxins, and resolving abscesses as it promotes the functions of heart, liver and gallbladder channels(508).

6. Ju Hua (Flos Chrysanthemi Morifolii)
Ju Hua also known as chrysanthemum flower, a genus of chrysanthemum, belongs to the family Asteraceae, native to Asia and northeastern Europe. The sweet, bitter and slightly cold herb has been used in TCM as anti-inflammatory(511)(512)(513), antibiotic(514)(515), including andida albicans(519), analgesic(516) and antipyretic(517) agents and to benefit diabetes(518) by expelling wind, clearing heat and toxins as it promotes the functions of lung and liver channels(517).

7. Bo He (Herba Menthae Haplocalycis)
Bo he is also known as Mint, a genus of Mentha, belonging to the family Lamiaceae, native to the through the world. The acrid and cold herb has been used in TCM as anti-pyretic(520), antinociceptive(520)(521), antimicrobial(522)(523) including candida albicans(524)(525), antioxidant(522)(523) anti-inflammatory(526)(527) agents and to treat wind-heat(528) cause of infection(522)(523) by dispersing wind-heat(528) and clearing fire(528) as it promotes the functions of liver and lung channels(529).

8. Gan Cao (Radix Glycyrrhizae Uralensis)
Gan Cao is also known as Licorice, a genus of Glycyrrhiza, belonging to the family Fabaceae, native to southern Europe and parts of Asia. The sweet herb has been used in TCM as anti microbial(530)(531)(532), including candida akbicans(533)(534), antioxidant(530)(531), inflammatory(536)(537), and anti allergic(538)(539)(540) agents by tonifying spleen, benefiting qi, moistening lung as it promotes all 12 channels(535).

9. Etc.

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+ References
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(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN1, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
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(401) Traditional Chinese Medicine for Candidiasis(Traditional Chinese medicine information page)
(460) Huang Lian(Rhizoma Coptidis)
(461) Huang Lian(Complementary and Alternative Healing University)
(462) Study of the anti-MRSA activity of Rhizoma coptidis by chemical fingerprinting and broth microdilution methods by Luo JY1, Yan D2, Yang MH3.(PubMed)
(463) Comparative pharmacokinetics of active alkaloids after oral administration of Rhizoma Coptidis extract and Wuji Wan formulas in rat using a UPLC-MS/MS method by Chen Y1, Li Y, Wang Y, Yang Q, Dong Y, Weng X, Zhu X, Wang Y, Gong Z, Zhang R.(PubMed)
(464) Evaluation of antibacterial effect and mode of Coptidis rhizoma by microcalorimetry coupled with chemometric techniques by Kong W1, Wang J, Xiao X, Chen S, Yang M.(PubMed)
(465) Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species by Seneviratne CJ1, Wong RW, Samaranayake LP.(PubMed)
(466) Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS by Liu X1, Han Y, Peng K, Liu Y, Li J, Liu H.(PubMed)
(467) Seasonal Variation of Alkaloid Contents and Anti-Inflammatory Activity of Rhizoma coptidis Based on Fingerprints Combined with Chemometrics Methods by Li JY1, Wang XB1, Luo JG1, Kong LY2.(PubMed)
(468)Anticachectic effects of Coptidis rhizoma, an anti-inflammatory herb, on esophageal cancer cells that produce interleukin 6 by Iizuka N1, Miyamoto K, Hazama S, Yoshino S, Yoshimura K, Okita K, Fukumoto T, Yamamoto S, Tangoku A, Oka M.(PubMed)
(469)The antihyperglycemic effects of Rhizoma Coptidis and mechanism of actions: a review of systematic reviews and pharmacological research by Wang H1, Mu W1, Shang H1, Lin J1, Lei X1.(PubMed)
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(471) Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats by Zipeng Gong,1 Ying Chen,1 Ruijie Zhang,1 Yinghan Wang,1,2 Qing Yang,1 Yan Guo,1 Xiaogang Weng,1 Shuangrong Gao,1 Hailin Wang,1 Xiaoxin Zhu,1 Yu Dong,3 Yujie Li,1 and Yajie Wang1(Hindawi Publishing Corporation)
(472) Rhubarb tannins extract inhibits the expression of aquaporins 2 and 3 in magnesium sulphate-induced diarrhoea model by Liu C1, Zheng Y2, Xu W2, Wang H2, Lin N1.(PubMed)
(473) [Effects of Na-FA on gastrointestinal movement and gastric ulcer in mice].[Article in Chinese] by Li YM1, Li BC, Li P, Liu JZ, Cui JL, Mei ZQ.(PubMed)
(474) A clinical study on compound da huang (radix et Rhizoma rhei) preparations for improvement of senile persons' memory ability by Tian J1, Du H, Yang H, Liu X, Li Z.(PubMed)
(475) Inhibitory effect of Daesungki-Tang on the invasiveness potential of hepatocellular carcinoma through inhibition of matrix metalloproteinase-2 and -9 activities by Ha KT1, Kim JK, Lee YC, Kim CH.(PubMed)
(476) Da Huang(Complementary and Alternative Healing University)
(477) A study of Helicobacterium pylori and prevention and treatment of chronic atrophic gastritis by Zhang L1, Yang L, Zheng X.(PubMed)
(478) The Treatment of Modern Western Medical Diseases with Chinese Medicine: A ...By Bob Flaws, Philippe Sionneau. Page 131
(479) Advances in Viridans Streptococci Research and Treatment: 2011 Edition
(480) A Handbook of TCM Pediatrics: A Practitioner's Guide to the Care and ...By Bob Flaws. Page 101
(481) Antimicrobial activity of berberine alone and in combination with ampicillin or oxacillin against methicillin-resistant Staphylococcus aureus by Yu HH1, Kim KJ, Cha JD, Kim HK, Lee YE, Choi NY, You YO.(PubMed)
(482) Antimicrobial activity of Chinese medicine herbs against common bacteria in oral biofilm. A pilot study by Wong RW1, Hägg U, Samaranayake L, Yuen MK, Seneviratne CJ, Kao R.(PubMed)
(483) [Study on the Chinese herbal formula for treatment of vaginitis and the antimicrobial activity in murine models].[Article in Chinese] by Fu TT1, Wu JY, Wang L, Ma Y, Wang Y, Liu Y, Ding H.(PubMed)

(484) Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS by Liu X1, Han Y, Peng K, Liu Y, Li J, Liu H.(PubMed)
(485) Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species by Seneviratne CJ1, Wong RW, Samaranayake LP.(PubMed)
(486) Er-Miao-San, a traditional herbal formula containing Rhizoma Atractylodis and Cortex Phellodendri inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-κB pathway and MAPKs activation by Chen G1, Li KK2, Fung CH2, Liu CL2, Wong HL2, Leung PC3, Ko CH4.(PubMed
(487) The anti-inflammatory potential of Cortex Phellodendron in vivo and in vitro: down-regulation of NO and iNOS through suppression of NF-κB and MAPK activation by Choi YY1, Kim MH1, Han JM1, Hong J2, Lee TH3, Kim SH4, Yang WM5.(PubMed)
(489) The principle and technique of using Chinese drugs in the treatment of hypertension by Zhou C1, Yu Z, Li R, Tian Z.(PubMed
(490) Beneficial effects of Phellodendri Cortex extract on hyperglycemia and diabetic nephropathy in streptozotocin-induced diabetic rats by Kim HJ1, Kong MK, Kim YC.(PubMed
(491) [Observation of the curative effect of qingchang huashi recipe for treating active ulcerative colitis of inner-accumulation of damp-heat syndrome].[Article in Chinese] by He HH1, Shen H, Zheng K.(PubMed)
(492) Antipyretic and anti-asthmatic activities of traditional Chinese herb-pairs, Ephedra and Gypsum by Mei F1, Xing XF, Tang QF, Chen FL, Guo Y, Song S, Tan XM, Luo JB.(PubMed)
(493) Treatment of painful Modic type I changes by vertebral augmentation with bioactive resorbable bone cement by Masala S1, Anselmetti GC, Marcia S, Nano G, Taglieri A, Calabria E, Chiocchi M, Simonetti G.(PubMed)
(494) A comparative study with oral nifedipine, intravenous nimodipine, and magnesium sulfate in postoperative analgesia by Zarauza R1, Sáez-Fernández AN, Iribarren MJ, Carrascosa F, Adame M, Fidalgo I, Monedero P.(PubMed)
(495) Scorpion in Combination with Gypsum: Novel Antidiabetic Activities in Streptozotocin-Induced Diabetic Mice by Up-Regulating Pancreatic PPARγ and PDX-1 Expressions by Xie W1, Zhao Y, Gu D, Du L, Cai G, Zhang Y.(PubMed)
(496) Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections by Howlin RP1, Brayford MJ2, Webb JS1, Cooper JJ2, Aiken SS2, Stoodley P3.(PubMed)
(497) Comparing PMMA and calcium sulfate as carriers for the local delivery of antibiotics to infected surgical sites by McConoughey SJ1, Howlin RP, Wiseman J, Stoodley P, Calhoun JH.(PubMed)
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(499) Herbs that c;ear heat(Chapter 3)
(500) Shi Gao (Complementary and Alternative Healing University)
(501) Chemical constituents from the fruits of Forsythia suspensa and their antimicrobial activity by Kuo PC1, Chen GF2, Yang ML3, Lin YH1, Peng CC1.(PubMed)
(502) Isoforsythiaside, an antioxidant and antibacterial phenylethanoid glycoside isolated from Forsythia suspensa by Qu H1, Zhang Y, Chai X, Sun W.(PubMed)
(503) Antioxidant and antibacterial activity of two compounds (forsythiaside and forsythin) isolated from Forsythia suspensa by Qu H1, Zhang Y, Wang Y, Li B, Sun W.(PubMed)
(504) Forsythin inhibits lipopolysaccharide-induced inflammation by suppressing JAK-STAT and p38 MAPK signalings and ROS production by Pan X1, Cao X, Li N, Xu Y, Wu Q, Bai J, Yin Z, Luo L, Lan L.(PubMed)
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(506) Antiasthmatic action of dibenzylbutyrolactone lignans from fruits of Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea-pigs by Lee JH1, Lee JY, Kim TD, Kim CJ.(PubMed)
(507) A strategy for evaluating antipyretic efficacy of Chinese herbal medicines based on UV spectra fingerprints by Ni LJ1, Zhang LG, Hou J, Shi WZ, Guo ML.(PubMed)
(508) Lian qiao (Complementary and Alternative Healing University)
(509) Effects of forsythia fruit extracts and lignan on lipid metabolism by Cho SH1, Rhee SJ, Choi SW, Choi Y.(PubMed)
(510) Protective effects of Forsythia suspensa extract against oxidative stress induced by diquat in rats. Lu T1, Piao XL, Zhang Q, Wang D, Piao XS, Kim SW.(PubMed)
(511) Anti-inflammatory components of Chrysanthemum indicum flowers by Luyen BT1, Tai BH2, Thao NP2, Cha JY3, Lee HY3, Lee YM4, Kim YH5.(PubMed)
(512) Chrysanthemum indicum Linné extract inhibits the inflammatory response by suppressing NF-kappaB and MAPKs activation in lipopolysaccharide-induced RAW 264.7 macrophages by Cheon MS1, Yoon T, Lee do Y, Choi G, Moon BC, Lee AY, Choo BK, Kim HK.(PubMed)
(513) Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production by Pyee Y1, Chung HJ, Choi TJ, Park HJ, Hong JY, Kim JS, Kang SS, Lee SK.(PubMed)
(514) Rapid green synthesis of silver nanoparticles from Chrysanthemum indicum L and its antibacterial and cytotoxic effects: an in vitro study by  Arokiyaraj S1, Arasu MV2, Vincent S3, Prakash NU4, Choi SH5, Oh YK1, Choi KC2, Kim KH6.(PubMed)
(515) Composition and antibacterial activity of essential oils from leaf, stem and root of Chrysanthemum parthenium (L.) Bernh. from Iran by Shafaghat A1, Sadeghi H, Oji K.(PubMed)
(516) Analgesic activity of the aqueous fraction from the ethanolic extract of Chrysanthemum indicum in mice by Chen YF1, Zhao MH, Yan M, Shi GB, Hou GX, Huang Y, Wang X, Zhao QC.(PubMed)
(517) Ju hua (Complementary and Alternative Healing University)
(518) Chrysanthemum Promotes Adipocyte Differentiation, Adiponectin Secretion and Glucose Uptake by Yamamoto J1, Yamane T, Oishi Y, Shimizu M, Tadaishi M, Kobayashi-Hattori K.(PubMed)
(519) The chemical constituents of endophytic fungus Trichoderma sp. MFF-1 by Li GH1, Wang XB, Liu FF, Dang LZ, Li L, Yang ZS, Xin X, Zhang KQ.(PubMed)
(520) Antipyretic and antinociceptive properties of Mentha longifolia Huds. (Lamiaceae) leaf aqueous extract in rats and mice by Amabeoku GJ1, Erasmus SJ, Ojewole JA, Mukinda JT.(PubMed)
(521) Antinociceptive activity of Mentha piperita leaf aqueous extract in mice by Taher YA1.(PubMed)
(522) Antimicrobial and antioxidant activities of three Mentha species essential oils. Mimica-Dukić N1, Bozin B, Soković M, Mihajlović B, Matavulj M.(PubMed)
(523) Chemical composition and antimicrobial and antioxidant activities of Mentha (longifolia L. and viridis) essential oils by Mkaddem M1, Bouajila J, Ennajar M, Lebrihi A, Mathieu F, Romdhane M.(PubMed)
(524) Effects of Mentha suaveolens Essential Oil Alone or in Combination with Other Drugs in Candida albicans by Stringaro A1, Vavala E2, Colone M1, Pepi F3, Mignogna G4, Garzoli S3, Cecchetti S5, Ragno R3, Angiolella L2.(PubMed)
(525) Anti-Candida activity of Mentha arvensis and Turnera ulmifolia by Santos KK1, Matias EF, Souza CE, Tintino SR, Braga MF, Guedes GM, Nogueira LF, Morais EC, Costa JG, Menezes IR, Coutinho HD.(PubMed)
(526) Chemical Composition and Anti-Inflammatory, Cytotoxic and Antioxidant Activities of Essential Oil from Leaves of Mentha piperita Grown in China by Sun Z1, Wang H2, Wang J3, Zhou L3, Yang P1.(PubMed)
(527) Anti-inflammatory effect of Mentha longifolia in lipopolysaccharide-stimulated macrophages: reduction of nitric oxide production through inhibition of inducible nitric oxide synthas by Karimian P1, Kavoosi G, Amirghofran Z.(PubMed)
(528) Pocket Atlas of Chinese Medicine By Marnae C. Ergil, page 269
(529) Bo he(Complementary and Alternative Healing University)
(530) Identification of antimicrobial and antioxidant constituents from licorice of Russian and Xinjiang origin by Okada K, Tamura Y, Yamamoto M, Inoue Y, Takagaki R, Takahashi K, Demizu S, Kajiyama K, Hiraga Y, Kinoshita T.(PubMed)
(531) Antioxidant and antimicrobial constituents of licorice: isolation and structure elucidation of a new benzofuran derivative by Demizu S, Kajiyama K, Takahashi K, Hiraga Y, Yamamoto S, Tamura Y, Okada K, Kinoshita T.(PubMed)
(532) Antimicrobial flavonoids from Glycyrrhiza glabra hairy root cultures by Li W, Asada Y, Yoshikawa T.(PubMed)
(533) 18β-glycyrrhetinic acid induces immunological adjuvant activity of Th1 against Candida albicans surface mannan extract by Kim J1, Joo I, Kim H, Han Y.(PubMed)
(534) Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans by Messier C1, Grenier D.(PubMed)
(535) Gan cao(Complementary and Alternative Healing University)
(536) Glabridin, An isoflavan from licorice root, down-regulates iNOS expression and activity under high glucose stress and inflammation by Yehuda I1, Madar Z, Leikin-Frenkel A, Tamir S.(PubMed)
(537) Anti-inflammatory effects of Huangqin tang extract in mice on ulcerative colitis by Chen P1, Zhou X2, Zhang L2, Shan M2, Bao B2, Cao Y2, Kang A2, Ding A2.(PubMed)
(538) Modulatory effects of several herbal extracts on avian peripheral blood cell immune responses by  Dorhoi A1, Dobrean V, Zăhan M, Virag P.(PubMed)
(539) Attenuation of allergic airway inflammation in a murine model of asthma by Licochalcone A by Chu X1, Jiang L, Wei M, Yang X, Guan M, Xie X, Wei J, Liu D, Wang D.(PubMed)
(540) Interaction of gypsum and the rhizome of Anemarrhena asphodeloides plays an important role in anti-allergic effects of byakkokakeishito in mice by Makino T1, Shiraki Y, Mizukami H.(PubMed)

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