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Thursday, 12 June 2014

Phytochemical Sulforaphane (Dithiolthiones) and Colon cancer

Dithiolthiones are phytochemicals in the class of Organosulfides, found abundantly in cruciferous vegetables, garden sorrel, horseradish, etc.

Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way. Bowel cancer is the third most commonly diagnosed cancer in developed countries, including US and Canada.
According to 1INRA, Laboratoire des Xénobiotiques, sulforaphane inhibited colon cancer cell line (HT29) through cell cycle arrest via an apoptotic process(1). GE132+Natural, a novel supplement consisting  Resveratrol, Ganoderma lucidum, Sulforaphane, Lycopene and Royal jelly, in the testing of tested cancer cell lines (PC3, MCF7 and SW480), is found to be effective in inhibiting all tested cancer cell proliferation, the University of Belgrade insisted(2). Other study also showed the effective of sulforaphane and related dietary isothiocyanates in treating colon cancer cells via induction of cell growth arrest, autophagy and apoptosis depending on the isothiocyanates (ITCs)  and treatment conditions(3).
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References
(1) Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells by Gamet-Payrastre L1, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S, Gasc N, Tulliez J, Tercé F.(PubMed)
(2) GE132+Natural: Novel promising dietetic supplement with antiproliferative influence on prostate, colon, and breast cancer cells by Okic-Djordjevic I1, Trivanovic D, Krstic J, Jaukovic A, Mojsilovic S, Santibanez JF, Terzic M, Vesovic D, Bugarski D.(PubMed)
(3) HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates by Rajendran P1, Kidane AI, Yu TW, Dashwood WM, Bisson WH, Löhr CV, Ho E, Williams DE, Dashwood RH.(PubMed)