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Wednesday, 18 June 2014

Phytochemical Polysulfides and colon cancer

Kyle J. Norton

Polysulfides are phytochemicals in a class of chemical compounds containing chains of sulfur atoms, belonging to the group of Organosulfides found abundantly in ioxidized product, including beer, wine, whiskey, garlic oil, etc.
Bowel cancer also known as colorectal cancer, is defined as a condition of the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. Bowl is divided in 2 parts, the first part of the bowel, the small bowl, is involved with the digestion and absorption of food. The 2nd part, the large bowel which consist the the colon and rectum, is involved in absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be re absorbed and reused by the body. Bowel cancer is relatively very common and slowly growing and progress cancer and in predictable way.
Bowel cancer is the third most commonly diagnosed cancer in developed countries, including U>S and Canada.
According to the study of the University of the Saarland, coumarin polysulfides showed to inhibit cell growth and induce apoptosis in HCT116 colon cancer cells, through regulated the phosphatase activity of the cell cycle regulating cdc25(Cell division cycle 25, family of dual-specificity phosphatases) family members(1). Diallylsulfides, another family member of Garlic-derived organo sulphur compounds, also inhibited HCT116 human colon cancer cells, through reduced cell viability, cell cycle arrest and apoptosis(2) and colo 205 human colon cancer cells through affected resistant gene expression(3)

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Reference
(1) Coumarin polysulfides inhibit cell growth and induce apoptosis in HCT116 colon cancer cells by Saidu NE1, Valente S, Bana E, Kirsch G, Bagrel D, Montenarh M.(PubMed)
(2) Diallylpolysulfides induce growth arrest and apoptosis by Busch C1, Jacob C, Anwar A, Burkholz T, Aicha Ba L, Cerella C, Diederich M, Brandt W, Wessjohann L, Montenarh M.(PubMed)
(3). Diallyl sulfide, diallyl disulfide and diallyl trisulfide affect drug resistant gene expression in colo 205 human colon cancer cells in vitro and in vivo by Lai KC1, Kuo CL, Ho HC, Yang JS, Ma CY, Lu HF, Huang HY, Chueh FS, Yu CC, Chung JG.(PubMed)