Tuesday, 8 April 2014

Phytochemical allicin and Stomach cancer

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

The health effects 
Allicin, even though is the least studied in scientific community, but its antitumor properties is undeniable in research. Study of the underlying mechanism of allicin on gastric cancer cells, allicin induced  apoptosis  and inhibited proliferation in gastric cancer cells, through induced cytochrome c release from the mitochondria and increased caspase-3, -8, and -9 activation, with concomitant upregulation of bax and fas expression in the tumor cells. In the effect of allicin on cell proliferation and apoptosis of progressive gastric carcinoma, allicin showed effects in up-regulating the protein expressions of apoptosis promoting gene Bax and apoptosis initiating gene Fas, and down-regulating that of anti-apoptosis gene Bcl-2 via local application of allicinvia gastroscopy.

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(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)

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