Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Stomach cancer
is defined as condition of abnormal growth of the mucus-producing cells
of the inside lining of the stomach. Adenocarcinoma is the most common
type of stomach cancer.
The health effects
Allicin, even though is the least studied in scientific community, but its antitumor properties is undeniable in research. Study of the underlying mechanism of allicin
on gastric cancer cells, allicin
induced apoptosis and inhibited proliferation in gastric cancer cells,
through induced cytochrome c release from the mitochondria and
increased
caspase-3, -8, and -9 activation, with concomitant upregulation of bax
and fas expression in the tumor cells. In the effect of allicin on cell
proliferation and apoptosis of progressive gastric carcinoma, allicin showed
effects in up-regulating the protein expressions of apoptosis promoting
gene Bax and apoptosis initiating gene Fas,
and down-regulating that of anti-apoptosis gene Bcl-2 via local application of allicinvia gastroscopy.
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References
(1) Allicin induces apoptosis in gastric
cancer cells through activation of both extrinsic and intrinsic pathways
by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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