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Tuesday, 1 April 2014

Phytochemical Allicin and malaria

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Malaria, a mosquito-borne infectious disease caused by parasitic protozoans

The health effects
Malaria has infected millions of people a year in the third world. The urgency in finding a natural existence agent in treating the diseases with less economical cost is become necessary. Allicin, found in garlic, may be one of them, as it enhanced the immune reponses of the host to reduce parasitaemia and prolong the survival of the host in a dose-dependent manner. In vivo, mice injected with allicin had found to decrease the levels of Plasmodium infections compared to controls, prevent  sporozoites cause of malaria when allicin was injection into mice before induction. orally or intravenously of allicin also significantly decreased parasitemias and increased the survival of infected mice by 10 days.


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References
(1) Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection by Feng Y, Zhu X, Wang Q, Jiang Y, Shang H, Cui L, Cao Y.(PubMed)
(2) Antimalarial activity of allicin, a biologically active compound from garlic cloves by Coppi A, Cabinian M, Mirelman D, Sinnis P.(PubMed)