Wednesday, 9 April 2014

Food therapy - Celery and Colon Cancer

Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.

1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins 
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Celery and Colon Cancer
Colon cancer is relatively very common and slowly growing and progress cancer and in predictable way and is the third most commonly diagnosed cancer in developed countries, including US and Canada.
Luteolin is 3',4',5,7-tetrahydroxyflavone found abundantly in celery showed in regulation of cell cycle progression and apoptosis in the HT-29 human colon cancer cell line, through inhibited CDK2, decreased levels of Cyclin D1 levels and promoted G2/M arrest via certain mechanisms(b)(c). In the study of a total of 336 incident cases of histologically confirmed colorectal cancer (111 colon cancer and 225 rectal cancer in Harbin city, the Harbin Medical College found that increased consumption of green vegetables, including celery, have a strong protective effect against colorectal cancer(d).
According to Dr. Belanger JT, Perillyl alcohol,a monoterpene isolated from the essential oils of  celery seeds was active in inducing apoptosis in tumor cells without affecting normal cells and can revert tumor cells back to a differentiated state, including colon cancer cells(e).

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(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin by Lim do Y1, Jeong Y, Tyner AL, Park JH.(PubMed)
(c) Carotenoids and colon cancer by Slattery ML1, Benson J, Curtin K, Ma KN, Schaeffer D, Potter JD.(PubMed)
(d) Diet and cancer of the colon and rectum: a case-control study in China by Hu JF1, Liu YY, Yu YK, Zhao TZ, Liu SD, Wang QQ.(PubMed)
(e) Perillyl alcohol: applications in oncology by Belanger JT.(PubMed)

1 comment:

  1. 3'-Geranyl-3-prenyl-2',4',5,7-tetrahydroxyflavone is a natural flavonoid found in the root bark of Morus alba. 3\'-Geranyl-3-prenyl-2\',4\',5,7-tetrahydroxyflavone