A bone cancer is an abnormal growth of cells within the bone that have became cancerous. Bone cancer may be classified as primary cancer originated in the bone, and secondary cancer originated from elsewhere.
The health benefits Aloe emodin have been found to effective in induced cell anti proliferation and apoptosis in some cancer cell line. In U87 human malignant glioma cells, the chemical constituent found in Cascara Sagrada,
arrested the cell cycle in the synthesis phase of the cell cycle and promoted the loss of mitochondrial membrane potential in U87 cells, leading to early event of mitochondria-induced apoptotic pathway. In other study of dimethylsulfoxide (DMSO; control) or aloe-emodin (40 microM) showed the effective of Aloe-emodin in inducing apoptosis in U-373MG glioma cells by suppressed PKC(a family of protein) activity and reduced the protein content of most of the PKC isozymes. These results support the positive effect of aloe-emodin and may be considered as a potential agent in treating human malignant glioma cells.
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(1) Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin by Ismail S, Haris K, Abdul Ghani AR, Abdullah JM, Johan MF, Mohamed Yusoff AA.(PubMed)
(2) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells by Acevedo-Duncan M, Russell C, Patel S, Patel R.(PubMed)