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Friday, 4 April 2014

Phytochemical allicin and pancreatic cancer

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Cancer of pancreas or pancreatic cancer is defined as condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably. Most pancreatic cancers start in the ducts (exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue accounts for over 75 - 90% of all cases of exocrine cancers.

The health benefits
Allicin found in garlic and onion has drawn many interest in scientific community in finding a natural potent agent with little and no side effects in preventing and treating cancers. Garlic preparations inhibition of cancer cell-growth has been attributed to a group of structurally-related organosulfur compounds, such as allicin, diallyl disulfide and diallyl trisulfide. Combined treatment with recombinant interleukin-2 (rIL-2) on pancreatic cancer and explored the potential immunological mechanism in mice, showed a significant suppression of cells growth and prolonged survival time in the combined treatment with allicin and rIL-2 group, with increased mature Th cells express the surface protein CD4 and CD8, natural killer cell (NK cell) and Serum levels of interferon-gamma.



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References
(1) Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI.(PubMed)