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Sunday, 13 April 2014

Food Therapy - Celery and cholesterol

Celery is a species of Apium graveolens, belonging to the family Apiaceae. It is cultivated all around the globe as a vegetable. Celery can grow to 1/2 m tall with stalks (leaf on the top) arranging in a conical shape joined at a common base.

Nutrients
1. Carbohydrates
2. Sugars
3. Fiber
4. Fat
5. Protein
6. Water
7. Vitamin A
8. Vitamin B1
9. Vitamin B2
10. Vitamin B6
11. Vitamin C
12. Vitamin K
13. Folate
14. Calcium
15. Manganese
16. Magnesium
17. Phosphorus
18. Potassium
19. Iron
20. Sodium
21. Etc.

Phytochemicals
1. 3-n-butyl-phthalide
2. Acetylenics,
3. Coumarins 
4. Phenolic acids
5. Limonene, coumarin,
6. Phthalides
7. Apigenin
and falcariondiol (1), (9Z) 1,9-heptadecadiene-4,6-diyne-3,8,11-triol (2), oplopandiol (3), bergapten (4), 5,8-dimethoxy psoralen (5), isofraxidin (6), eugenic acid (7), trans-ferulic acid (8), trans-cinnamic acid (9), p-hydroxyphenylethanol ferulate (10), caffeoylquinic acid (11), 5-p-trans-coumaroylquinic acid (12), sedanolide (13), lunularin (14), lunularic acid (15), 2-(3-methoxy-4-hydroxyphenol)-propane-1,3-diol (16), D-allitol (17), beta-sitosterol (18), benzolic acid (19), succinic acid (20), according to Shenyang Pharmaceutical University(a).
Celery and cholesterol
Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place. If you have too much low density lipoprotein LDL that is known as bad cholesterol, overtime cholesterol can build up in your arterial walls causing blockage and leading to heart attack and stroke.
The study of the composition of ethanolic extract of seeds of Apium graveolens L. and its chloroform and aqueous basic fraction in olive oil on induced hyperlipidemic rats inhibited the total cholesterol (TC) triglycerides (TG),  low density lipoproteins (LDL) level, and significantly increased high density lipoprotein (HDL) in does depended manner(b). Mountain celery seed essential oils (MC-E)' ether fractionate and 1,1-diphenyl-2-picrylhydrazyl exhibited strong hypolipidemic and  free radical scanvenging activities, repectively, according to the Da-Yeh University(c). Other study in the genetically hypercholesterolaemic (RICO) rat model, aqueous celery extract, oral admisnistion for 8 weeks induced a significant reduction in serum total cholesterol (TC) level(d)(e)(f).


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References
(a) [Chemical constituents of fresh celery].[Article in Chinese] by Zhou K1, Wu B, Zhuang Y, Ding L, Liu Z, Qiu F(PubMed)
(b) Effect of chloroform and aqueous basic fraction of ethanolic extract from Apium graveolens L. in experimentally-induced hyperlipidemia in ratsm by Iyer D1, Patil UK(PubMed)
(c) Hypolipidemic and antioxidant activity of mountain celery (Cryptotaenia japonica Hassk) seed essential oils by Cheng MC1, Lin LY, Yu TH, Peng RY.(PubMed)
(d) The mechanism underlying the hypocholesterolaemic activity of aqueous celery extract, its butanol and aqueous fractions in genetically hypercholesterolaemic RICO rats by Tsi D1, Tan BK.(PubMed)
(e) Effects of celery extract and 3-N-butylphthalide on lipid levels in genetically hypercholesterolaemic (RICO) rats by Tsi D1, Tan BK.(PubMed)
(f) Effects of aqueous celery (Apium graveolens) extract on lipid parameters of rats fed a high fat diet by Tsi D1, Das NP, Tan BK.(PubMed)