Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.
Allicin, a biologically active component in freshly crushed garlic extract, in the study of its effects against colon cancer cell lines HCT-116, LS174T, HT-29, and Caco-2, showed that allicin exert it anti proliferative property to cause death of HCT-116 cell. Other in the study of the effect of allicin on human colon cancer cell line LoVo and the combined effect of allicin and CPT-11 on this cancer cell line, showed that allicin may be a potent agent in treating colon cancer as it not only exerted the anti-proliferation effect on human colon cancer cell line LoVo by induction of apoptosis and arrestment of cell cycle but also enhanced the cytotoxicity of CPT-11 on the colon cancer LoVo cell.
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(1) Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 by Bat-Chen W, Golan T, Peri I, Ludmer Z, Schwartz B.(PubMed)
(2) [Allicin enhances cytotoxicity of CPT-11 to colon cancer LoVo cell in vitro].