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Sunday, 20 April 2014

Food Therapy - Apricot and liver cancer

The apricot tree is about 8–12 m tall and a trunk up to 40 cm diameter belongs to the family Rosaceae. Apricot is classified with the family of the plum and has yellow to orange, often tinged red on the side which is exposed to the sun.

Nutrients

1. Energy
2. Carbohydrates
3. Dietary fiber
4. Fat
5. Protein
6. Vitamin A
7. Beta-carotene
8. Vitamin C
9. Iron
10. Potassium
11. Tryptophan
12. Carotenoids
13. Etc.

Chemical constituents
Oleic acid, linoleic acid,  palmitic.acid, glycolipids, phospholipids, benzoic acid (I), isorhamnetin (II), quercetin (III), kaempferol-3-O-beta-D-galactopyranoside (IV), isorhamnetin-3-O-beta-D-glucopyranoside (V), isoquercitrin (VI), hypericin (VII) and rutin (VIII)(a) and flavonoid glycosides(b).
Apricot and liver cancer
MK615 is produced from Japanese apricot and contains several cyclic triterpenes.It's  oleanolic and ursolic acids have shown to strongly suppress cutaneous in-transit metastasis in a patient with malignant melanoma(1). In liver cancer, MK615 showed to inhibited liver cancer cell line lines, HuH7 and Hep3B, through increased the population of cells in G2/M phase. and suppressed the expression of Aurora A(1). The Takasaki General Center Hospital study also on extract Mk615, in advanced hepatocellular carcinoma, the application showed  a positive effccts in decreased alpha-fetoprotein level and both the lymph node and pulmonary metastases in size and  prolonged survival in a 60-year-old female underwent surgical resection of a 9 cm HCC in the right lobe(2).



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 References
(1) Antitumor effect of Japanese apricot extract (MK615) on human cancer cells in vitro and in vivo through a reactive oxygen species-dependent mechanism by Hattori M1, Kawakami K, Akimoto M, Takenaga K, Suzumiya J, Honma Y.(PubMed)
(1) A novel anti-cancer substance, MK615, from ume, a variety of Japanese apricot, inhibits growth of hepatocellular carcinoma cells by suppressing Aurora A kinase activity by Okada T1, Sawada T, Osawa T, Adachi M, Kubota K.(PubMed)
(2) Advanced hepatocellular carcinoma responds to MK615, a compound extract from the Japanese apricot "Prunus mume" by Hoshino T1, Takagi H, Naganuma A, Koitabashi E, Uehara S, Sakamoto N, Kudo T, Sato K, Kakizaki S.(PubMed)