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Thursday, 3 April 2014

Phytochemical allicin and Osteosarcoma

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Osteosarcoma is a bone cancer found mostly in teenagers and people over age 60.
The health benefits
Phytochemical compounds derived from garlic such as Allicin, diallyl thiosulfinate, have been drawn of interest in cancer treatment research. In the study of the effects of artesunate combined with allicin on osteosarcoma cell lines in vitro and in vivo, found that treatment with artesunate and allicin enhanced the synergistic effects on osteosarcoma cell proliferation and apoptosis. diallyl sulfide (DAS) derived from allicin, in the study of its effect on proliferation of human osteosarcoma MG-63 cells, showed to significantly suppress the growth of MG-63 tumor-bearing tissue. Immunohistochemistry in different concentrations (20 and 40 μg/mL) and decrease microvessel density (MVD) of MG-63 tumor-bearing tissue by suppressing the expression of Vascular endothelial growth factor (VEGF) mRNA.
References
(1) The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo by Jiang W, Huang Y, Wang JP, Yu XY, Zhang LY.(PubMed)
(2) Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells by Hu Y, Chen L, Yi C, Yang F, Chen J.(PubMed)