Monday, 7 April 2014

Phytochemical allicin and endometrium cancer

Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.

The benefits
Although garlic has drawn many interest in scientific community, but believe or not allicin is the least. In the study of the effect of allicin's antiproliferative effect in vitro models, showed a significantly inhibited proliferation of human mammary (MCF-7), endometrial (Ishikawa), and colon (HT-29) cancer cells (50% inhibitory concentration = 10-25 microM)  attributed to the ability of allicin to transiently deplete the intracellular GSH level(1). Other study also indicated that
this main flavor compound in garlic, has exerted its anti-carcinogenic activities against a wide range of cancer cells. U87MG  is one of a number of cell lines derived from malignant glioma was inhibited, causing apoptosis of cells by allicin in a dose- and time-dependent manner, involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ERK signaling pathway and antioxidant enzyme systems(2).

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(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y.(PubMed)
(2) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH.(PubMed)

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