Devil's claw also known as wood spider, is a plant of genus Harpagophytum in the family of Pedaliaceae, native to
South Africa.The plant has been used as herb in traditional and herbal
medicine to treat fever, rheumatoid arthritis, skin, gallbladder,
pancreas, stomach and kidneys conditions, etc.
Health benefits
1. Antiinflammatory effects
In the investigation of Harpagophytum procumbens (Hp) and it effect on inflammatory and degenerative disease, found that standardized ethanol Hp extract from Harpagophytum
procumbensinhibits induction of pro-inflammatory gene expression,
possibly by blocking the AP-1 pathway. This is novel evidence of a
possible mechanism of action of this antiinflammatory drug, according to
"Molecular Targets of the Antiinflammatory Harpagophytum procumbens (Devil's claw): Inhibition of TNFα and COX-2 Gene Expression by Preventing Activation of AP-1." by Fiebich BL, Muñoz E, Rose T, Weiss G, McGregor GP.(1)
2. Osteoarthritis
In the observation of Harpagophytum procumbens and it effects on chronic inflammatory conditions such as Osteoarthritis found that Devil's Claw
appeared effective in the reduction of the main clinical symptom of
pain. The assessment of safety is limited by the small populations
generally evaluated in the clinical studies. From the current data,
Devil's Claw
appears to be associated with minor risk (relative to NSAIDs), but
further long-term assessment is required, according to the study of "Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety" by Brien S, Lewith GT, McGregor G.(2)
3. Cholinesterases Inhibitory and Antioxidant Activities
In the investigation of extracts of cell suspension and transformed root cultures of Harpagophytum procumbens (commonly known as Devil's claw)
and it antioxidants effect found that indicated that the
phenylethanoid fractions may be attractive for various commercial
purposes since they displayed significant cholinesterase inhibitory
activity (even higher than that of pure galanthamine in the case of
butyrylcholinesterase inhibition assay). Crude methanolic extracts from
cell and hairy root cultures of Devil's claw
exhibited strong ferrous ion-chelating capacity (1.5-2 times higher
than pure butylated hydroxyanisole, used as positive standard),
according to the study of "Cholinesterases Inhibitory and Antioxidant Activities of Harpagophytum procumbens from In Vitro Systems" by Georgiev MI, Alipieva K, Orhan IE.(3)
4. Osteoarthritis
In the study of Devil's Claw (Harpagophytum
procumbens) and it effects on osteoarthritis found that fourteen
studies were identified: eight observational studies; 2 comparator
trials (1 open, the other randomized to assess clinical effectiveness);
and 4 double-blinded, placebo-controlled, randomized controlled trials
to assess efficacy. Many of the published trials lacked certain
important methodological quality criteria. However, the data from the
higher quality studies suggest that Devil's Claw appeared effective in the reduction of the main clinical symptom of pain, according to the study of "Devil's Claw (Harpagophytum procumbens) as a treatment for osteoarthritis: a review of efficacy and safety" by Brien S, Lewith GT, McGregor G.(4)
5. Uterotonic effect
In the analying some traditional health practitioners of South Africa have claimed that Harpagophytum
procumbens DC (family: Pedaliaceae) secondary root is a useful
obstetric remedy for induction or acceleration of labour, found that the
herb provoked powerful contractions of isolated longitudinal, tubular
uterine horn muscle preparations of non-pregnant and pregnant rats. The
results of this in vitro study indicate that H. procumbens secondary
root aqueous extract possesses spasmogenic, uterotonic action on
mammalian uterine muscles, according to "Uterotonic effect of Harpagophytum procumbens DC (Pedaliaceae) secondary root aqueous extract on rat isolated uterine horns' by Mahomed IM, Ojewole JA.(5)
(6) Analgesic, antiinflammatory and antidiabetic effects
In the investigation of Harpagophytum
procumbens DC (Family: Pedaliaceae). H. procumbens is widely used in
South African traditional medicine for the treatment, management and/or
control of a variety of human ailments found that H. procumbens root
aqueous extract possesses analgesic, antiinflammatory and hypoglycaemic
properties, and lend pharmacological support to the suggested folklore
uses of Harpagophytum
procumbens root in the management and/or control of painful, arthritic
and other inflammatory conditions, as well as for adult-onset, type-2
diabetes mellitus in some communities of South Africa, according to the
study "Analgesic, antiinflammatory and antidiabetic properties of Harpagophytum procumbens DC (Pedaliaceae) secondary root aqueous extract' by Mahomed IM, Ojewole JA.(6)
7. Degenerative diseases of the musculoskeletal system
Extracts of the secondary tubers of Devil's Claw (Harpagophytum
procumbens) and it degenerative painful rheumatism effects found that
Pharmacological experiments have shown analgesic, antiphlogistic and
antiinflammatory actions. Most important constituents are iridoid
glycosides, which are supposed to contribute mainly to the observed
effects. However, the entire extract has to be considered as active
ingredient, according to"[Therapy of degenerative diseases of the musculoskeletal system with South African devil's claw (Harpagophytum procumbens DC)].[Article in German]" by Wegener T.(7)
8. Arthrosis of hip or knee
In observation of Preparations made from the secondary tubers of Devil's claw (Harpagophytum
procumbens) and it effects on rheumatic diseases (arthrosis and low
back pain) found that a continuous improvement in typical clinical
findings such as 45.5% for pain on palpation, 35% for limitation of
mobility and 25.4% for joint crepitus. Only two cases of possible
adverse drug reactions were reported (dyspeptic complaints and a
sensation of fullness), according to "Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC.)" by Wegener T, Lüpke NP.(8)
9. Low back pain
In the analyzing Harpagophytum procumbens and it osteoarthritis and low back pain effects found that the use of an aqueous extract of Harpagophytum
procumbens at 60 mg harpagoside being non-inferior to 12.5 mg
rofecoxib per day for chronic non-specific low-back pain (NSLBP) in the
short term. Strong evidence exists for the use of an aqueous Harpagophytum
extract at a daily dose equivalent of 50 mg harpagoside in the
treatment of acute exacerbations of chronic NSLBP., according to the
study of "Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review" by Gagnier JJ, Chrubasik S, Manheimer E.(9)
10. Anticonvulsant activity
In the examination of Harpagophytum
procumbens DC [family: Pedaliaceae] as a herbal medicine in South
African traditional medicine and its anticonvulsant activity found that
the anticonvulsant property of the herb may be linked, at least in
part, to its ability to depress the central nervous system. However, the
results of this experimental animal study indicate that H. procumbens
secondary root aqueous extract possesses anticonvulsant activity, and
thus lend pharmacological support to the suggested folkloric,
ethnomedical uses of the plant's extract in the treatment, management
and/or control of epilepsy and childhood convulsions in some rural
communities of South Africa, according to the study of "Anticonvulsant activity of Harpagophytum procumbens DC [Pedaliaceae] secondary root aqueous extract in mice" by Mahomed IM, Ojewole JA.(10)
11. Etc.
Side Effects
1. Do not use Devil'sclaw if you have gastric or duodenal ulcers
2. Do not use the herb if you have gallstones
3. the herb may interact with other medicine
4. Do not use the herb if you are pregnant or breast feeding with out permission of related field specialist
5. Do not use Devil's claw if you are taking lower blood sugar medicine.
6. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22072539
(2) http://www.ncbi.nlm.nih.gov/pubmed/17212570
(3) http://www.ncbi.nlm.nih.gov/pubmed/21721061
(4) http://www.ncbi.nlm.nih.gov/pubmed/17212570
(5) http://www.ncbi.nlm.nih.gov/pubmed/19907121
(6) http://www.ncbi.nlm.nih.gov/pubmed/15742343
(7) http://www.ncbi.nlm.nih.gov/pubmed/10483693
(8) http://www.ncbi.nlm.nih.gov/pubmed/14669250
(9) http://www.ncbi.nlm.nih.gov/pubmed/15369596
(10) http://www.ncbi.nlm.nih.gov/pubmed/16464685
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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