1. Anti tumopr activity
Researchers at the University of Macau, in the study to compare the effectiveness of yanhusuo (Rhizoma Corydalis) and Ezhu (Rhizoma Curcumae) in treating tumors, indicated that a combination of two herbal extracts exhibits the strongest anticancer cell proliferation effect at the ratio of 3:2 (ezhu to yanhusuo; referred to as E3Y2). Using Boyden Chamber assay, flow cytometry, and fluorescence microscopy analysis, we found that E3Y2 could markedly reduce the cell invasion ability and induce cytochrome c release rather than single use, but E3Y2 could not influence the cell cycle distribution. When the levels of ERK1/2, p-ERK1/2 and p-Rb were determined by Western blot analysis, we found that the E3Y2 significantly suppresses the level of p-ERK(1).
2. Breast cancer
Yanhusuo extract inhibits metastasis of breast cancer cells by modulating mitogen-activated protein kinase signaling pathways, according to the study at the University of Macau(2).
3. Antiangiogenic effects
In the study to expose the antiangiogenic effects and the underlying mechanisms of C. yanhusuo and the alkaloids obtained from this plant, found that antiproliferative activities of several main constituents of C. yanhusuo, which belong to a group of protoberberine alkaloids, on HUVECs identified berberine as a powerful angiogenesis inhibitor in C. yanhusuo. Both C. yanhusuo extract and its active compound berberine significantly suppressed the VEGF-induced upregulation of matrix metalloproteinase 2 (MMP2) at both mRNA and protein levels(3).
4. Anti-inflammatory effects
In the study of the anti-inflammatory effects of Tetrahydropalmatine, an alkaloid compound found in plants, including Corydalis yanhusuo, showed that tetrahydropalmatine inhibited LPS-induced IL-8 production in a dose-dependent manner. Furthermore, tetrahydropalmatine inhibited extracellular signal-regulated kinase and p38 MAPK phosphorylation, which suggests that tetrahydropalmatine inhibits IL-8 secretion by blocking MAPK phosphorylation. Taken together, these findings may help elucidate the mechanism by which tetrahydropalmatine modulates THP-1 cell activation under inflammatory conditions(4).
1. Do not use in case of blood heat and Qi spleen deficiency
2. Prolonged period usage can be toxic to the liver and damage
3. Do not use the herb in newborn, children or if you are pregnant or breast feeding without first consulting with the related field specialist.
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