Turmeric Protects the Cervix Against the Risk of Cervical Cancer in Vitro

By Kyle J. Norton

The cervix is the lower part of the uterus that opens at the top of the vagina. The cervix acts a transition area for vaginal lining (squamous epithelium) to uterus type (columnar epithelium) through the transitional area (squamous columnar epithelium) to host the development of the fetus.

Cervical cancer is a medical condition caused by cells grown abnormally in the cervix uteri or cervical area due to the alternation of cells DNA.

Most cases of cervical cancer begin in the cells on the surface of the inner lining tissue in the cervix uteri or cervical area before penetrating into deeper layers to form a tumor by proliferation.

According to the statistics provided by the  American Cancer Society, in 2019, approximately 13,170 new cases of invasive cervical cancer will be diagnosed and cervical cancer will cause the death of  4,250 American women.

Today, due to the introduction of the pep test, the cervical cancer death rate has dropped significantly as cancer can be diagnosed at a very early stage. Most cases of cervical cancer are diagnosed in women at the ages of 35 and 44.

The 5-year survival overall rate for all women with cervical cancer is 66%. However, the 5-year survival rate in women with invasive cervical cancer diagnosed at the early stage is 92%.

Pre-cervical cancer is the early stage of abnormal cell changes in the cervical tissue, if left untreated, the incidence can develop into true invasive cervical cancer.

Gardasil, a vaccine,  has been used to prevent pre-cervical cancer from the infection of two types of HPV approved by the U.S. Food and Drug Administration in 2006. It is for women benefits to take this vaccine if you are sexually active with several partners.

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

In the urgency to find a potential compound for the treatment of cervical cancer, researchers investigated the anti-cervical cancer activity of curcumin in vitro.

According to the tested assays, in human cervical cancer HeLa cells curcumin-induced cell death through the induction of DNA damage, and chromatin condensation. 

More precisely, the efficacy of curcumin at 13 µM increased the protein levels associated with DNA damage and repair, leading to cancer cells apoptosis on the early onset of cervical cancer.

Additionally, in HPV infections related to HPV 16 and 18 types, that cause cervical cancer, researchers evaluated curcumin chemopreventive and anticancer effects against both HPV-related and nonrelated cervical cancers. 

In benzo(a)pyrene (Bap), carcinogen-induced pathological cervical lesions of women who smoke, administration of curcumin exerted a significant effect in the inhibition of Bap induced signaling pathway and molecular markers dysregulation.

In other words, proteins associated with the early onset of cervical cancer caused by benzo(a)pyrene (Bap) were inhibited the injection of curcumin by reducing levels of oxidative stress marker.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of cervical cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Curcumin causes DNA damage and affects associated protein expression in HeLa human cervical cancer cells by Shang HS1, Chang CH2, Chou YR3, Yeh MY4, Au MK5, Lu HF6, Chu YL7, Chou HM8, Chou HC8, Shih YL8, Chung JG. (PubMed)
(2) Curcumin as a multifaceted compound against human papilloma virus infection and cervical cancers: A review of chemistry, cellular, molecular, and preclinical features by Teymouri M1, Pirro M2, Johnston TP3, Sahebkar A. (PubMed)
(3) Cervical Cancer by Kyle J. Norton