Sunday, 30 June 2019

Phytochemical Alliin the Anti Liver Cancer Bioactive Ingredient

By Kyle J. Norton

Liver cancer is a medical condition caused by irregular cell growth in the liver tissue.

According to the statistics assessed by the cancer experts, in 2019, approximately 42,030 adults (29,480 men and 12,550 women) in the United States will be diagnosed with primary liver cancer. 

Believe it or not, since 1980, the incidence of liver cancer has tripled. Between 2006 and 2015, the number of people diagnosed with the disease increased by approximately 3% annually.

Most common preventable causes of liver cancer are excessive alcohol drinking over time, chronic infection by hepatitis B and C, and cirrhosis.

Types of liver cancer include
* Hepatocellular carcinoma, the most common type of liver cancer accounting for 75 percent of all cases.

* Cholangiocarcinoma is a cancer of the bile duct, which is the small, tube-like bile ducts in the liver that carry bile to the gallbladder to help with digestion.

* Liver Angiosarcoma is a rare form of liver cancer that develops quickly and

* Hepatoblastoma also is a rare type of liver cancer found in children, particularly in those under age 3.

Most common symptoms of liver cancer are upper abdominal pain., abdominal swelling, jaundice and white, chalky stools, accompanied by general symptoms shared by other types of cancer including unintended weight loss, gastrointestinal discomfort, loss of appetite and persistent fatigue.

If you have experienced some of the aforementioned symptoms with no signs of receding, please make sure that you check with your doctor to rule out the possibility.

Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.

With an aim to find a potential ingredient for the treatment of liver cancer with little or no side effects, researchers in the cancer team at the Institut National de la Recherche Agronomique examined the increasing fertilization of soil resulted in an increased alliin content of the powders on liver cancer animal model.

According to the results, garlic powders administered to rats for 2 weeks (5% of the diet), administration of the different garlic powders demonstrated a 35-60% reduction in DNA damage induced by N-nitrosodimethylamine (NDMA) in rat liver.

In examining the increased alliin content of the garlic powder, researchers found that the presence of alliin was associated strongly with a proportional decrease in NDMA induced DNA alteration.

Believe it or not, the increased levels of alliin in the garlic powder content did not have additional effect in DNA damage induced by aflatoxin B1 in the liver or by 1,2-dimethylhydrazine in the colon, compared the efficacy in the liver. 

In other words, garlic powders regardless of the levels of alliin did not modify the genotoxic activity which is the direct-acting carcinogen methylnitrosourea in the colon.

Taken altogether, alliin may be considered a supplement for the prevention and treatment of liver cancer, depending on the confirmation of the larger sample size and multicenter human study.

Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Inhibition of carcinogen-induced DNA damage in rat liver and colon by garlic powders with varying alliin content by Singh V1, Belloir C, Siess MH, Le Bon AM. (PubMed)
(2) Effects of garlic powders with varying alliin contents on hepatic drug metabolizing enzymes in rats by Le Bon AM1, Vernevaut MF, Guenot L, Kahane R, Auger J, Arnault I, Haffner T, Siess MH.(PubMed)

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