Friday, 7 June 2019

Healthy Kitchen Spice Turmeric, a Natural Prevention and Treatment of Liver Cancer

By Kyle J. Norton

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above your stomach.

The liver not only plays a critical role to filter the blood coming from the intestine before passing them to other parts of the body but also protects our body against toxin by detoxifying chemicals and metabolizes drugs.

Futhermore, the liver produces bile that not only aid the digestive function in food absorption but also builds strong cell membranes, produces vitamin D and steroid hormone.

Additionally, the liver also inhibits oxidative stress by producing the antioxidant enzyme that counters the expression of free radicals in the body

Liver cancer is a medical condition characterized by out of controlled growth of hepatocellular cells in the liver. Most cases of liver cancer start in the cells on the surface of the inner lining of the liver tissue, before penetrating into deeper layers to form a tumor.

At the advanced stage, primary liver cancer can also travel a distance away to infect other healthy tissues and organ, leading to secondary metastasis.

Since the liver is an organ with soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer. 

According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide. In the US, approximately 42,030 new cases including 29,480 in men and 12,550 in women will be diagnosed with liver cancer. The liver cancer also will cause of 31,780 American, including 21,600 men and 10,180 women in 2019.

Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

Most common symptoms of liver cancer are abdominal pain, tenderness, easy bruising or bleeding, enlarged abdomen, jaundice, severe pain, particularly in the later stage and drowsiness and confusion accompanied by the general symptoms shared by other types of cancer.

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding potential and natural compound for the treatment of liver cancer, researchers investigated curcumenol and laminarin, the bioactive compounds found in turmeric and kelp respectively.
In vitro, according to the tested assays, the combination of curcumenol and laminarin inhibited the proliferation, migration, and invasion in human hepatoma HepG2 cells.

Furthermore, the combination of curcumenol and laminarin also has a strong effect on the inhibition of HepG2 cell proliferation and metastasis.

In other words, the efficacy of the combination was attributed to the inhibition of the expression of the levels of cystathionine beta-synthase (CBS, an endogenous hydrogen sulfide (H2S) synthetase) level associated with cancer initiation and progression

Where the increased expression of cystathionine beta-synthase has been found in cancer cells of various tissue types.

Moreover, the combined production also blocked the angiogenesis of liver cancer cell by positively regulating the vascular endothelial growth factor (VEGF).

Based on the finding, researchers wrote, " the combination of Curcuma zedoary and kelp could inhibit the proliferation and metastasis of liver cancer cells in vivo and in vitro by inhibiting endogenous H2S production and down-regulating the pSTAT3/BCL-2 (apoptotic) and VEGF (metastatic) pathway".

Additionally, in the examined secondary liver cancer caused by primary gastric cancer (PGC) metastasis, researchers found that injection of curcumin, an active ingredient from the rhizome of the plant Curcuma longa reduces the incidence of metastatic tumor formation in the liver in vivo.

In mice induced primary gastric cancer treated with curcumin treatment, the circulating tumor cells (CTCs) significantly reduced the formation of liver tumor.

More precisely, curcumin also blocked the expression of CXCR4 in primary tumor cells associated with the cancer cells survival, metastasis, and recurrence.

Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of primary and secondary liver cancer, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Combination of Curcuma zedoary and kelp inhibits growth and metastasis of liver cancer in vivo and in vitro via reducing endogenous H2S levels by Han H 1, Wang L, Liu Y, Shi X, Zhang X, Li M, Wang T. (PubMed)
(2) Curcumin inhibits liver metastasis of gastric cancer through reducing circulating tumor cells by Gu X1, Zhang Q1, Zhang W2, Zhu L. (PubMed)

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