Metastasis is a process in which cancer cells travel a distance away from the originated site to induce secondary malignant growths.
Scientists in the urgency to find the natural compound for the treatment of cancer examined the effect of Cucurbitacin B (CuB), a plant triterpenoid found abundantly in cucumber against the metastatic and angiogenic potential of breast cancer cells.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis by Sinha S1, Khan S1, Shukla S1, Lakra AD1, Kumar S2, Das G3, Maurya R2, Meeran SM. (PubMed)
(2) Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis by Shukla S1, Sinha S1, Khan S1, Kumar S2, Singh K3, Mitra K3, Maurya R2, Meeran SM. (PubMed)
(3) Targets for anti-metastatic drug development by Stock AM1, Troost G, Niggemann B, Zänker KS, Entschladen F. (PubMed)