Herbal Turmeric Processes the Lung Protective Against Respiratory Diseases in Vitro and Vivo

By Kyle J. Norton



 Lung protection is an action in which substances, including herbal remedies, are used to protect the lung against injury or damage.

The lungs are a pair of organs located on either side of the chest (thorax) with a function to bring fresh oxygen into the body and remove the carbon dioxide and other waste gases from the body.

According to the statistics provided by the Lung Association over 3 million Canadians are affected by one of five serious respiratory diseases – asthma, chronic obstructive pulmonary disease (COPD), lung cancer, tuberculosis (TB), and cystic fibrosis.

In 2017, 28,600 Canadians were diagnosed with lung cancer, represented 14% of all new cancer cases. Lung cancer caused the death of 21,100 Canadians in the same year.

The exact causes of lung disease are not identified. However, epidemiological studies suggested
being overweight, smoking, family history, smoking are some of the most prevalent factors associated with the onset of the disease.

Most common lung diseases in North America including asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease, pulmonary hypertension, and cystic fibrosis.

Symptoms of lung disease are totally depending on the type of disease.

Out of many risk factors, occupational lung diseases are one of the most challenging in the modern world.

Dr. Sara De Matteis, the lead scientist wrote, "New occupational agents with unknown respiratory health effects are constantly introduced to the market and require periodic health surveillance among exposed workers to detect early signs of adverse respiratory effects".

And, "In addition, the aging workforce, many of whom have pre-existing respiratory conditions, poses new challenges in terms of the diagnosis and management of occupational lung diseases".

Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound which processes respiratory protective effects, researchers examined the anti-inflammatory properties through down-regulating inflammatory cytokines of curcumin on acute lung injury in mouse peritoneal macrophages by ELISA.

All 30 curcumin analogs included in the study. the bioactive ingredient showed a strong effect in the inhibition of production of proinflammatory cytokines (TNF-α and IL-6) induced by the injection of LPS.

In vitro, some compound exhibited anti-inflammatory activity in a dose-dependent manner and greater stability compared to that of curcumin.

In vivo, SD rats pretreatment with a curcumin analog (c26) for seven days and then intratracheally injected with LPS to induce acute lung injury (ALI) was found to inhibit the increased protein concentration and number of inflammatory cells, pathological changes of lung tissue, inflammatory cytokines in serum and inflammatory gene expression caused by LPS.

Compared to another curcumin analog, c26 has remarkable protective effects on LPS-induced ALI in rats.

In other words, the efficacy of curcumin against acute lung injury was associated with the presence of component c26.

Taken altogether, turmeric may be considered a supplement for the prevention and combined with primary medicine for the treatment of glioblastoma and resistant glioblastoma, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury by Zhang Y1, Liang D2, Dong L3, Ge X4, Xu F5, Chen W6, Dai Y7, Li H8, Zou P9, Yang S10, Liang G. (PubMed)
(2) Curcumin pretreatment prevents potassium dichromate-induced hepatotoxicity, oxidative stress, decreased respiratory complex I activity, and membrane permeability transition pore opening by García-Niño WR1, Tapia E, Zazueta C, Zatarain-Barrón ZL, Hernández-Pando R, Vega-García CC, Pedraza-Chaverrí J. (PubMed)
(3) Current and new challenges in occupational lung diseases by Sara De Matteis, Dick Heederik, Alex Burdorf, Claudio Colosio, Paul Cullinan, Paul K. Henneberger, Ann Olsson, Anne Raynal, Jos Rooijackers, Tiina Santonen, Joaquin Sastre, Vivi Schlünssen, Martie van Tongeren, Torben Sigsgaard. (European Respiratory Review)