Friday, 28 June 2019

Cucumber's Cucurbitacin B (CuB), Promotes Antimicrobial Activity

By Kyle J. Norton

Antimicrobial activity is the process that either kills or inhibits the microorganisms that induce damage to the body tissues.

In other words, antimicrobial activity is the process of killing or inhibiting the disease-causing microbes, including the use of antibiotics for treatment of infectious disease caused by bacterias and fungi.

Most common diseases associated with microbial infection include
* Diseases caused by bacteria are totally dependent on the types of bacterias, such as pneumonia, caused by Streptococcus and Pseudomonas, and foodborne illnesses caused by bacteria such as Shigella, Campylobacter, and Salmonella.

* Diseases caused by the virus include smallpox. the common cold and different types of flu. measles, mumps, rubella, chicken pox, and shingles. hepatitis. herpes and cold sores. polio. rabies, Ebola and Hanta fever.

* Diseases caused by parasites are malaria, trichomoniasis, giardiasis, cryptosporidiosis, and toxoplasmosis.

* Diseases caused by fungi aspergillosis usually occurs in patients with lung diseases or weakened immune systems and Candidiasis is caused by the yeast Candida.

Depending on the types of microbial infection, most common symptoms are fever, diarrhea, fatigue, muscle aches, and coughing

The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.

With an aim to find a natural compound with antibiotic property, researchers investigated extracts purified by dialysis and ion exchange chromatography strategy antibacterial activity against four standard pathogenic bacterial strains.

According to the tested assays, the elute fractions 1 and 3 (370 mg/mL) showed the greatest anti-bacterial activity compared to elute fractions 2 and 4 (340 mg/mL).

Furthermore, among the bacteria utilized, E. coli was clearly the most sensitive compared to other strains.

Additionally, according to the bioassay-guided isolation from the chloroform fraction of the crude methanol extract of cucumber (Cucumis sativus L.) stems induced (2S,3S,4R,10E)-2-[(2'R)-2-hydroxytetra-cosanoylamino]-1,3,4-octadecanetriol-10-ene (1), 1-O-β-D-glucopyranosyl(2S,3S,4R,10E)-2-[(2'R)-2-hydroxy-tetracosanoylamino]-1,3,4-octadecanetriol-10-ene (2) and soya-cerebroside I (3), compound 1 showed a relatively low polarity aglycone but exhibited stronger antimicrobial activity than its corresponding glycoside 2.

Dr. Tang J, the lead scientist wrote, "The results indicated that sphingolipids could be the main antimicrobial compounds in the crude methanol extract of cucumber stems".

Taken altogether, cucumber processed a high amount of phytochemicals may be used for the treatment of bacterial infection, pending to the confirmation of the larger sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Purification and MIC analysis of antimicrobial proteins from Cucumis sativus L. seeds by Al Akeel R1, Mateen A1, Alharbi KK1, Alyousef AA1, Al-Mandeel HM2, Syed R. (PubMed)
(2) Antimicrobial activity of sphingolipids isolated from the stems of cucumber (Cucumis sativus L.) by Tang J1, Meng X, Liu H, Zhao J, Zhou L, Qiu M, Zhang X, Yu Z, Yang F. (PubMed)

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