Angiogenesis is a process involved in the migration, growth, and differentiation of endothelial cells, that stimulates the growth of new blood vessel from the existing vessel.
Under normal conditions, angiogenesis is necessary for wound healing, tissues repairment in which the developing or healing tissues receive an adequate supply of nutrients.
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a potent compound which processes anti-angiogenetic activity against cancer proliferation and invasion, researchers examined the apo-10'-lycopenoic acid (ALA), a derivative of lycopene on liver and lung cancer animal models.
* Higher lycopene intake was inversely associated with total prostate cancer and more strongly with lethal prostate cancer.
In other words, higher lycopene intake reduced cancer proliferation by stimulating the formation of the new blood vessel.
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Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
(1) Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor γ by Cheng J1, Miao B1, Hu KQ1, Fu X1, Wang XD. (PubMed)
(2) Dietary lycopene, angiogenesis, and prostate cancer: a prospective study in the prostate-specific antigen era by Zu K1, Mucci L, Rosner BA, Clinton SK, Loda M, Stampfer MJ, Giovannucci E. (PubMed)
(3) Anti-angiogenic strategies for cancer therapy (Review) by Benouchan M1, Colombo BM. (PubMed)