Healthy Food Onion Inhibits the Initiation and Progression of Gastrointestinal Tract Cancer

By Kyle J. Norton

Digestive cancer is a group of medical conditions associated with irregular cell growth in the tissue on the gastrointestinal tract.

Most cases of gastrointestinal cancer begin in the cells on the surface of the inner lining in a specific organ, before penetrating into deeper layers to form a solid tumor through proliferation.

Most common cancers of the gastrointestinal tract are 

*Esophagus

The esophagus or gullet is the tube that leads foods from the pharynx to the stomach. 

Esophageal cancer is caused by abnormal cell growth in the cells that line the upper part of the esophagus or glandular cells in the lower part of the esophagus that connected with the stomach.

Esophageal cancer starts from the lining of the esophagus, then later penetrate in the wall of the esophagus and spread to the lymph node around the bottom of the esophagus, stomach and the chest.

* Gallbladder cancer

The gallbladder is a small organ under the liver with a function that aids the digestive system in fat metabolism with storing bile produced by the liver.

Gallbladder cancer arises from the cells of the tissue of the gallbladder. It is common cancer in central and South America, central and eastern Europe, Japan and northern India, but rare in North America.

*Liver cancer

The liver is the largest internal organ located in the upper right portion of the abdomen, beneath your diaphragm and above the stomach.

Liver cancer is a condition caused by the uncontrolled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most cases of liver cancer are diagnosed in the later stage of cancer. 

According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.

*Pancreas cancer

The pancreas is an oblong flattened gland in the digestive and endocrine system located in the abdomen. 

By secreting pancreatic juice to the small intestine, pancreas helps to break down carbohydrates, proteins, and lipids.

Cancer of pancreas or pancreatic cancer is a chronic condition associated with irregular cell growth in the ducts (an exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue which accounts for over 75 - 90% of all cases of exocrine cancers.

*Stomach cancer

Stomach located between the esophagus and the small intestine is a muscular, hollow and an important organ of the digestive tract.

Stomach cancer is a condition characterized by abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.

* Bowel cancer

Human Bowl is divided into 2 parts,  the small bowel, is associated with the digestion and absorption of food.  large bowel including the colon and rectum that involve absorption of water from the small bowel contents and break down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body. 

Bowel cancer is a condition caused by the abnormal proliferation of cells in the colon, rectum, or vermiform appendix. 

Bowel cancer is relatively very common and slowly growing and progressing in a predictable way.

Bowel cancer is the third most commonly diagnosed cancer in developed countries, including the US and Canada.

Besides some of the symptoms associated with specific types of cancer, most gastrointestinal cancers shared the general symptoms of unintended weight loss, loss of appetite, fatigue, nausea, and vomiting.

The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures. 

Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.

With an aim to find a potential compound for the treatment of cancer in the digestive system, researchers examined the relationship between total allium, garlic, and onion intake on the risk of cancer of the upper aerodigestive tract (UADT).

According to the results of data of published observational studies (21 case-control and four cohort studies), using a meta-analytic approach and random effects models, onion exerted the relative risk of 0.72 compared to 0.79 for total allium, 0.74 for garlic for the highest versus the lowest consumption.

 Total allium including onion consumption showed an inverse relation apparently stronger in case-control studies.

These results suggested that onion has a moderate inverse association with the risk of squamous cell carcinoma of the UADT.

Additionally, according to the University Laboratories of Medical Research (LURM) in the examination of the effects of dietary components on cancer of the digestive system, onion contains active components that can influence the initiation and progression of cancer.

Furthermore, these chemical compounds have also been found to inhibit cell proliferation and metastasis, induce apoptosis.

More precisely, onion protected the integrity and viability of the cells in the digestive system through it's antioxidant, cytotoxic, and pro-apoptotic properties.

Taken altogether, onion may be considered a remedy for the prevention and treatment of cancer of the digestive system, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Effects of dietary components on cancer of the digestive system by Zanini S1, Marzotto M, Giovinazzo F, Bassi C, Bellavite P. (PubMed)
(2) Allium vegetables and upper aerodigestive tract cancers: a meta-analysis of observational studies by Guercio V1, Turati F2, La Vecchia C1, Galeone C2, Tavani A. (PubMed)