Tuesday, 13 March 2018

The Secrets of ANTI Major Aging Signs Vitamin(3) in Enhanced (Type 1 & 4) Collagen, Smoothed Wrinkles and Inhibited Aging Spots, Fine Lines, Improved Overall Intensity of Pigmentation and More, Scientists Revealed

Skin aging is one of most visible process which occurs constantly in our skin organ.

According to the Clinical Centre of Nis, certain plant extracts may have the ability to scavenge free radicals, to protect the skin matrix through the inhibition of enzymatic degradation, or to promote collagen synthesis in the skin, affect skin elasticity and tightness(a).

Other suggested that free radicals induced domino effects in production of reactive oxygen species, can react with DNA, proteins, and fatty acids, causing oxidative damage and impairment of antioxidant system, leading injuries damage regulation pathways of skin, including wrinkles, roughness, appearance of fine lines, lack of elasticity, and de- or hyperpigmentation marks(b).

Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin, found in fresh fruits, berries and green vegetables.

The water soluble vitamin is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support. 

In skin aging, the vitamin may improve solar radiation protection and epidermal aging(1) through production of collagen due to its antioxidant activity(2)(3).

Epidemiological studies, linking vitamin C in prevention of skin damage and aging have produced some certain results(3a)(3b)(3c), but the large sample size and multi canters studies are necessary to validate it effectiveness.

L-ascorbic acid, was known for its effects on skin-whitening anti-oxidation causes of skin aging. 

During the aging process, levels of vitamin C was found slowly deplete, according to Tokyo Metropolitan Institute of Gerontology in the measurement of plasma and urine of C57BL/6 male mice turnover during 3 to 30 months of aging(4). 

Therefore, restoration of physiological levels of vitamin C inside the cells might improve the lysosomal degradation (protection of cell from the degradative enzymes, through protection of the cytosol) in the outflow pathway cells and prevent the pathogenesis of glaucomadegrade proteins(5).

Unfortunately, some researchers suggested that higher levels of circulating vitamin C may not provide protection against incident radiographic knee OA, and be associated with an increased risk of knee OA(6).

Panorama Research Institute and Regenerative Sciences Institute, insisted "careful attention to individual and family medical history and personal genomic data may prove essential to make wise dietary and supplement choices to be combined with exercise(7).

According to the Minghsin University of Science and Technology, in doses dependent manner, concentration of L-ascorbic acid, induced absorption of the collagen solution in exhibition of smoothing wrinkles and clear up the spots(8). 

Ascorbic acid (AA) is essential in stimulation for collagen gene expression. In type 1 and type 4 collagen and SVCT2, the vitamin was found to enhance the expression of type 1 and type 4 collagens and SVCT2 mRNA in cultured human skin fibroblasts at 100 μM AA placed every 24h for 5 days to prevent depletion(9). 

The Chiang Mai University study also supported the effects of ascorbic acid in anti-aging process through exhibition pro and active MMP-2 inhibitory(10). 

Other study suggested the combined vitamins, including vitamin C in a single formulation had a slightly lower degradation rate and more stable formulations as compared to different preparations containing only one of the vitamins(11)(12). 

Amazingly, in vivo, application of vitamin C showed a significant reduction of oxidative stress in the skin, an improvement of the epidermal-dermal microstructure and a reduction of fine lines and wrinkles in aged skin within a relatively short period of time of product application(13). 

The Bruce and Associates study also insisted the effectiveness of vitamin C application over 12 week period as the vitamin enhanced the overall intensity of pigmentation, fine lines and wrinkles, tactile roughness, and laxity with 100% of satisfied overall appearance of tested subject skin(14).

Taken altogether, vitamin C was found to be effective in slowdown skin aging regardless to the cause, through its antioxidant status, down regulated the expression of Matrix metalloproteinase (MMPs) and enhanced production of collagens. Daily ingestion of high-dose vitamin Cmay be considered safe, but in rare incidence, overdoses in a prolonged period of time, may cause intra-renal oxalate crystal deposition, a fatal nephrotoxicity(15)(16).

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(a) Skin ageing: natural weapons and strategies by Binic I1, Lazarevic V, Ljubenovic M, Mojsa J, Sokolovic D.(PubMed)
(b) Phytoconstituents as photoprotective novel cosmetic formulations by Saraf S1, Kaur CD.(PubMed)
(1) Hass avocado composition and potential health effects by Dreher ML1, Davenport AJ.(PubMed)
(2) The effects of a daily facial lotion containing vitamins B3 and E and provitamin B5 on the facial skin of Indian women: a randomized, double-blind trial by Jerajani HR1, Mizoguchi H, Li J, Whittenbarger DJ, Marmor MJ(PubMed)
(3) A bioactive complex to protect proteins from UV-induced oxidation in human epidermis, by Schweikert K1, Gafner F, Dell'Acqua G.(PubMed)
(4) Protective effects of a cream containing Dead Sea minerals against UVB-induced stress in human skin by Portugal-Cohen M1, Soroka Y, Ma'or Z, Oron M, Zioni T, Brégégère FM, Neuman R, Kohen R, Milner Y.(PubMed)
(5) Topical use of dexpanthenol in skin disorders by Ebner F1, Heller A, Rippke F, Tausch I.(PubMed)
(6) Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation by Proksch E1, Nissen HP.(PubMed)

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