Fennel may have a potential and positive effect in modulated the effect of chemo drugs through its chemomodulatory activity, some scientists suggested.
The expression of fennel application in enhanced chemopreventive response was evident in animal models from the reduced tumor burden in reduced cancer cells proliferation and apoptosis and reduced percentage of tumor through some different publications.
The results were reported by several respectable institute including Jawaharlal Nehru University and published on online medical literature.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
According to the Jawaharlal Nehru University, in evaluate the chemopreventive effect of different doses of test diet of Foeniculum vulgare Mill (Fennel) seeds on DMBA-induced skin and B(a)P-induced forestomach papillomagenesis in Swiss albino mice, application of fennel seeds displayed a significant reduction in the skin and the forestomach tumor incidence and tumor multiplicity as compared to the control group.
Dr. Singh B, the lead author said, "A significant enhancement in the activities of antioxidant enzymes were observed especially at 4% and 6%" and "glyoxalase I(with function as enzymatic defence against glycation) activity and the content of reduced glutathione (antioxidant) were significantly elevated".
Additionally, in the examine the effect of fennel bioactive compound anethole in chemomodulatory activity against the onset and spread of cancer, researchers found that application of fennel oil by inhibited the activated expression of NF-kappa B, a gene-altering and inflammation in triggering molecule in development of various solid tumors through stimulated cancer proliferation.
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Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(1) Chemomodulatory action of Foeniculum vulgare (Fennel) on skin and forestomach papillomagenesis, enzymes associated with xenobiotic metabolism and antioxidant status in murine model system by Singh B1, Kale RK(PubMed)
(2) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
(3) Arzoo and Milind Parle, Pharmacology Division, Department of Pharm. Sciences, Guru Jambheshwar University of Science and Technology(EUROPEAN JOURNAL OF PHARMACEUTICALAND MEDICAL RESEARCH)