Monday, 19 March 2018

Better than Aspirin Single Herb in Inhibited Platelet Aggregation to Prevent Onset of Cardiovascular Disease without Any Adverse Effects

Arnica may have a profound and positive effect in inhibited platelet aggregation, thus reducing risk of cardiovascular disease, some scientists suggested.

Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, antive to Europe and Asia, used in herbal medicine for centuries to treat strains, sprains, and bruises.
Wound healing is process of repairing after damage of skin, tissues, organs, etc.

The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative.

In the study of several plants extract including Arnica to evaluate anti-platelet and cytotoxic effects on blood platelets, researchers found that  flowers of arnica (A. montana) extract exhibited a significant effect in on platelet reactivity and cell viability, according to assays from standard method.

According to the flow cytometric monitoring of platelet cytotoxicity, application of phenolic acid-rich extract of Arnic at doses of 7.5 and 15 µg/ml significantly reduced Adenine di-Phosphate (ADP)-induced aggregation in both whole blood and platelet-rich plasma (PRP).

Further analysis also suggested that the extract decreased the platelet reactivity index (PRI; VASP phosphorylation) used as markers for clinical outcomes in non-ST elevation acute coronary syndrome in whole blood, through its antioxidant capacity.

Interestingly,  Arnica extract displayed huge suppressed platelet hyper-reactivity, without influenced  interfering cytotoxity.

These results indicated that high polyphenol content of flower extract of Arnica consisted an excellent antioxidant capacity and exceptional anti-platelet properties in compared to the application of the extract of J. regia husks in reduced ADP-induced platelet aggregation in whole blood and PRI at doses of  7.5 µg/ml and 15 µg/ml. 

According to the a randomized clinical trial conducted by the Canadian Family Physician, with 18 patients selected from the Centre Hostipatier of Laval University  divided into 2 group. group A received Arnica 5CH at frist visit and 2 week later received placebo and group B receievd reverse application as of group A.

In the analysis along the period of experiment,  one patient was excluded from the study due to bleeding over 9.5 minutes in compared to only 5 minutes of the normal baseline.

Group A exerted an increase of bleeding time of .59 minutes in compared to reduce of .26 minutes in group B all in compared to normal bleeding time at the baseline.

Application of Arnica showed an significant effect in Fibrinogen (factor I), a glycoprotein circulates in the blood with function to converted enzymatically by thrombin to fibrin and subsequently to a fibrin-based blood clot during injure without affecting the PT, PTT, platelet count and pro coagulant activity.

Moreover application of Arnica also exerted no significant modification of platelet aggregation in application of 4 dilution collagen, ADP and epinephrine in compared the increased levels of platelet aggregation of collagen, ADP and epinephrine  after 3 weeks  of treatment in the study of 39 patients.

The conflict result of the study may be caused by several reasons, including
* The nature of patients condition
* Doses of Arnica with a strong implication of blood coagulation was not mentioned used in the experiment 
* The types of test use was not clarified 
And the result was not statistic analysis.

Taken together, Arnica as whole herb and its flower extract may have potential effect in inhibited platelet aggregation in induced risk of bleeding. However. due to conflict results, additional large example size conducted by mutli centers are necessary to re affirm the viability.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

(1) Comparison of cytotoxic and anti-platelet activities of polyphenolic extracts from Arnica montana flowers and Juglans regia husks by Rywaniak J1, Luzak B, Podsedek A, Dudzinska D, Rozalski M, Watala C.(PubMed)
(2) The effects of Arnica Montana in Bleeding Time, A randomized Clinical Trial by  Canadian Family Physician

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