What is Cancer
Cancer
is a class of diseases in which a group of cells growing and
multiplying disordered and uncontrollable way in our body, have become
progressively worse and damaged other healthy tissues, sometimes spreads
to other organs in the body via lymph or blood and results may be in
death.
The growth of normal cells
Under
normal circumstance, cell growth is a natural process without even
notice, everyday millions of cell grow to replace millions of dead cells
and to keep our body in balance and healthy.
Sometimes,
acceleration of cells growth is necessary to prevent further damage to
the body organ, such as cut, injure, etc., but after fulfilling their
purposes, the growth of cells are back to normal rate again due to our
body growth inhibitors. Unfortunately, skin cells sometimes overgrow
while healing, leading to scar to the skin.
The primary tumor; size and growth
A primary tumor
or original tumor is a tumor that is at the original site where it
first arose where tumor progression began and proceeded to yield a
cancerous mass. Some types of cancer can begin in several place, such as
lymphomas and leukemias. Most cancers can not be detected until they
formed a lump as little as a grape. A cancer cells need 42 doubling
before itcan produce enough cancer cells to cause death.
How cancer cell invade neighbor cells
If the cancer cells grow to its tumor size, they may also invade and kill their neighbor cells by producing
abnormal or excessive signaling chemicals (hormones or cytokines)
which upset the normal chemical balance of the body and alter the
metabolic pathways, leading to disordered and violent cellular
behavior.
Distance spread
There
are many ways cancer causes of distant formation of secondary
cancers1. Local spreading, lymph vessel, blood vessel1.1. Local
spreading as soon as the cancer cells grow to its tumor size, it will
invade the nearby area. The reason of its action still unknown, but
researchers suspect
a. As the tumor grows, it needs more space by pressing on the nearby normal body tissue nearby naturally for its own survival.
b. Enzyme
Tumors
contain large amount of enzymes produced by the cancerous cells to
ensure their survival by breaking down the nearby tissues, making a
pathway for itself to invade the healthy tissue. Scientists have
discovered a substance made by cancer cells which plays a big part in
the local spread of cancers.
1.2. Spread through lymph vessel
If
some cancer cells detached from the primary tumor and travel can grow
into a secondary cancer but most of time they are trapped in the nearby
lymph nodes closest to the original tumor.
1.3. Spread through blood circulation
Similar
to spread through lymph vessel, cancer cells detached from origanl
tumor can enter the blood stream by slipping pass the blood vessel wall
and start grow into the secondary tumor as they are trapped into some
small capillaries.
It may sound horrible, but only one out of thousands survive this journal to form a secondary cancer or metastasis.
2. Travel of clumps of cancer along the channels
Out
of the above, sometimes, cancer cells detached from the primary tumor
can travel through other channels, but they do not spread randomly,
because some parts of the body are more vulnerable to becoming
metastatic sites than others.
3. Arrival of cancer cells at a distance site
The
development of the survival of cancer cells get trapped and grow into
second tumor is obvious, but researchers do not know how it can get out
of the trapping area to invade other organs of the body.
4. Angiogenesis
Angiogenesis
is defined as a process involving the growth of new blood vessels from
pre-existing vessels. As they arrived in area distancing from the
primary tumor. The secondary tumor can persuade the adjacent tissue to
build blood vessels by providing it with vital nutrients and oxygen,
because they are not also recognized by immune system as some foreign
substances.
5. Etc.
Causes of cancers
Cancers
are primarily an environmental disease with 90-95% of cases attributed
to environmental factors and 5-10% due to genetics.
Causes of cancer can be divided into 2 groups
A. Environmental cause
Most common environmental factors cause of cancers include tobacco, diet and obesity, infections,
radiation, lack of physical activity, and environmental pollutants.
Sometimes, The environmental factors can enhance abnormalities in the
genetic material of cells as s result of weakened immune system.
1. Chemicals
Chemicals
such as chlorinated hydrocarbons, asbestos, and hexavalent chromium,
have been shown to be carcinogenic can enhance DNA mutations, leading to
the growth of cancer. There are some chemicals which can
promote cancers by stimulating the rate of cell division, leading to
less time for repair enzymes to repair damaged DNA during DNA
replication, increasing the risk of cancer.
2. Diet
In the
United States obesity is associated with the development of many types
of cancer and is a factor in 14–20% of all cancer death. Even through
there are no direct link of obesity to cancer risk but it may have a
negative effects on immune system and endocrine system.
3. Infection
Worldwide approximately 18% of cancers are related to infectious diseases. There is an indication of which viruses are usual infectious agents that cause cancer but bacteria and parasites may also have an effect.
4. Radiation
Radiation
can cause cancer in most parts of the body, in all animals, and at any
age, although radiation-induced solid tumors usually take 10–15 years,
and up to 40 years, to become clinically manifest, and
radiation-induced leukemias typically require 2–10 years to appear, due
to radiation exposure, including both ionizing radiation and
non-ionizing radiation.
B. Hereditary genetic cause.
Due to abnormalities of certain class of gene in cells division and replication such as oncogenes and tumor suppressor genes.
C. Hormone
Some
hormones factor can enhance the development and spread of sex-related
cancer, such as cancer of the breast, endometrium, prostate, ovary, and
testis, and also of thyroid cancer and bone cancer.
D. Inflammation
Although
there is no evidence of inflammation caused caner, repeated injuries
to the same tissues might promote excessive cell division and
replication, thus increasing the risk of a cancerous mutation.
E. Etc.
Classification
Cancers are classified by the types of cell that have become malignant.
1. Carcinoma
Carcinoma is a malignant tumor found in anywhere of epithelial tissues lining the cavities, surfaces of structures and glands.
Although the forming of the malignant tumor in epithelium are still
unknown, but it possesses and associates the characteristics of
epithelial cells, including those of the breast, prostate, lung and
colon.
2. Sarcoma
Sarcoma is a type of cancer that arises from
malignantly connective tissue cells originated from embryonic germ
cells or bone, cartilage, and fat tissues and cells.
3. Lymphoma and leukemia:
Hematopoietic
cells are multipotent stem cells that give rise to all types of the
blood cell, including red blood cells, white blood cells, and platelets
become cancerous.
4. Germ cell tumor
Cancer derived from pluripotent cells. In adults these are most often found in the testicle and ovary, but are more common in babies and young children.
5. Blastoma
Cancer derived from immature "precursor" or embryonic tissue. These are also commonest in children.
Types of factor that cause cancers
1.
Aging: Due to weakened immune system as a result of wear and tear over
years. Some researchers suspected that free radicals may be one of
contributors.
2. Tobacco :Due to chemical causes of cells alternation
3. Sunlight :Damage to skin as result of ultra violet.
4. ionizing radiation: Any types of hazard chemicals cause of gene mutation
5. Virus and bacteria: As mentioned above
6. Hormones: Abnormal production of certain hormones can increase the risk of sex-related cancers
7. Family history : Check above
8. Etc.
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