Tuesday, 29 October 2013

Dementia Treatments of Wernicke-Korsakoff Syndrome In conventional Medicine Perspective

I. Dementia
About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability that is severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people. American typical diet contains high amount of saturated and trans fat, artificial ingredients with less fruits and vegetable which can lead to dementia and other kind of diseases

II. Treatment of  Wernicke-Korsakoff Syndrome due to long-term alcohol abuse
Wernicke-Korsakoff Syndrome due to long-term alcohol abuse is a type of dementia as a result of long term alcohol abuse causes of thiamine deficiency.
1. Initial treatment consists of reversing the thiamine deficiency by giving supplemental thiamine, usually beginning with an initial intravenous or intramuscular dose. Then followed by supplemental oral doses.
In Autopsy studies, some researchers suggest that Wernicke-Korsakoff Syndrome (WKS) is not a rare disorder, particularly in individuals who abuse alcohol. Thiamine has been established as the treatment of choice for over 50 years, but unfortunately, there are insufficient evidence from randomized controlled clinical trials to guide clinicians in the dose, frequency, route or duration of thiamine treatment for prophylaxis against or treatment of WKS due to alcohol abuse(1).
Other suggested that it is important to start the thiamine treatment before giving any glucose. In the study of initial symptoms, comorbidity, and alcohol withdrawal in 73 alcoholic patients with subsequent Korsakoff syndrome. In 25/73 (35%) of the patients the classic triad of Wernicke's encephalopathy with ocular symptoms, ataxia and confusion, was found. In at least 6/35 (17%) of the initial deliria (95% confidence interval: 10-25%), excluding other somatic causes, medication, (recent) alcohol withdrawal, or intoxication. We suggest that these deliria may have been representing Wernicke's encephalopathy. A high frequency (15%) of diabetics may reflect a contributing factor of diabetes mellitus in the evolution of the Wernicke-Korsakoff syndrome(2)

2. Side effects are not limit to
1. Rash
2. Itching/swelling
3. Severe dizziness
4. Trouble breathing
5. Etc.

Thiamine treatment usually can not reverse the loss of memory and intellect of Korsakoff psychosism but stopping alcohol use can prevent additional loss of brain function and damage to the  nerves.

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(1) http://www.ncbi.nlm.nih.gov/pubmed/14974055
(2) http://www.ncbi.nlm.nih.gov/pubmed/22332852

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