I. Dementia
About 5-8% of all people over the age of 65 have some
form of dementia, and this number doubles every five years above that
age.
Dementia is the loss of mental ability that is severe enough to
interfere with
people's every life and Alzheimer's disease is the most common type of
dementia
in aging people. American typical diet contains high amount of saturated
and trans fat, artificial ingredients with less fruits and vegetable
which can lead to dementia and other kind of diseases
II. Treatment of Wernicke-Korsakoff Syndrome due to long-term alcohol abuse
Wernicke-Korsakoff Syndrome due to long-term alcohol abuse is a type of
dementia as a result of long term alcohol abuse causes of thiamine
deficiency.
1. Initial treatment consists of reversing the thiamine deficiency by giving
supplemental thiamine, usually beginning with an initial intravenous or
intramuscular dose. Then followed by supplemental oral doses.
In Autopsy studies, some researchers suggest that Wernicke-Korsakoff Syndrome
(WKS) is not a rare disorder, particularly in individuals who abuse
alcohol. Thiamine has been established as the treatment of choice for
over 50 years, but unfortunately, there are insufficient evidence from randomized controlled clinical trials to
guide clinicians in the dose, frequency, route or duration of thiamine
treatment for prophylaxis against or treatment of WKS due to alcohol
abuse(1).
Other suggested that it is important to start the thiamine treatment before giving
any glucose. In the study of initial symptoms, comorbidity, and alcohol withdrawal in 73 alcoholic patients with subsequent Korsakoff syndrome. In 25/73 (35%) of the patients the classic triad of Wernicke's
encephalopathy with ocular symptoms, ataxia and confusion, was found.
In at least 6/35 (17%) of the initial deliria (95% confidence interval:
10-25%), excluding other somatic causes, medication, (recent) alcohol withdrawal,
or intoxication. We suggest that these deliria may have been
representing Wernicke's
encephalopathy. A high frequency (15%) of diabetics may reflect a
contributing factor of diabetes mellitus in the evolution of the Wernicke-Korsakoff syndrome(2)
2. Side effects are not limit to
1. Rash
2. Itching/swelling
3. Severe dizziness
4. Trouble breathing
5. Etc.
Thiamine treatment usually can not reverse the loss of memory and intellect of Korsakoff psychosism but stopping
alcohol use can prevent additional loss of brain function and damage to
the nerves.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/14974055
(2) http://www.ncbi.nlm.nih.gov/pubmed/22332852
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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