Dementia
About 5-8% of all people over the age of 65 have some
form of dementia, and this number doubles every five years above that
age.
Dementia is the loss of mental ability that is severe enough to
interfere with
people's every life and Alzheimer's disease is the most common type of
dementia
in aging people. American typical diet contains high amount of saturated
and trans fat, artificial ingredients with less fruits and vegetable
which can lead to dementia and other kind of diseases; As we age,
productions of hormone decrease gradually of that can effect the
cognitive function, leading to dementia, according to Eric R. Braverman,
MD in the article of Hormones Dementia, numerous studies have linked
hormone supplementation as protective in
the development of dementia regardless of whether or not these hormones
are deficient but more so when they are deficient. Hormonal deficiencies
that are linked are: Growth hormone beginning from age 30 in both men
and women, estrogen loss beginning at age 40 in women, testosterone loss
beginning at age 40 in men and DHEA loss beginning in both men and
women at age 50. The loss of luteinizing and sex binding globulin
hormones may also be associated with the development of dementia with
age(1)
E. Hormone Causes of Dementia
1. Growth hormone
A report at the Universidad de Barcelona, Barcelona showed that there is a physiological decline of the growth hormone (GH)/insulin-like growth
factor-I (IGF-I) axis with ageing, and the possibility that the
GH/IGF-I axis is involved in cognitive deficits has been recognized for
several years and the results of several studies addressing this point show varied
results: superimposable response of GH to GHRH than response of GH to
GHRH in controls; blunted GH to GHRH response in AD patients; higher GH
concentrations in the morning; greater increase of GH to GHRH in AD
patients than in controls(2). Other reported that evidence favoring this idea stems from the ability of both hormones to
stimulate beta amyloid release from neurons as well as by the
stimulatory effect that IGF-I exerts on brain amyloid clearance. In
addition, insulin and IGF-I levels are altered in Alzheimer's
patients and, probably in close association to these changes, cell
sensitivity towards insulin--and possibly also IGF-I--is decreased in
these patients.(3)
2. Estrogen
In the research of the association of decreased levels of estrogen and
dementia, Scientist at the Kings College London suggested that the
positive effects of estrogen are most
robust in young women and in older women who had initiated ET around the
time of menopause(4). Other study supported the hypothesis that estrogen-replacement therapy is associated with a reduced prevalence of Alzheimer's disease
in postmenopausal women. Prospective clinical trials are required to
enable women and their physicians to weigh risks and benefits of estrogen-replacement therapy for the prevention of dementia(5)
3. Testosterone
In a study of a group of 28 older men with either subjective memory loss or dementia, serum total testosterone
and sex hormone binding globulin (SHBG) correlated inversely with
plasma levels of amyloid beta peptide 40 (Abeta40, r=-0.5, P=0.01 and
r=-0.4, P=0.04, respectively), researchers at Fremantle Hospital, showed
that lower androgen levels are associated with increased plasma Abeta40
in older men with memory loss or dementia, suggesting that subclinical androgen deficiency enhances the expression of Alzheimer's disease-related peptides in vivo(6).
4. DHEA
Kyushu University, in the study of a decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) in patients with Alzheimer's disease (AD), indicated that patients with AD and patients with CVD were found to have lower concentration of serum DHEA-S and a lower DHEA-S/DHEA ration compared to normal control individuals. No significant difference was observed in the concentration of serum DHEA-S or the DHEA-S/DHEA ratio between patients with AD and those with CVD. These results suggest that reduced concentrations of serum DHEA-S may not be unique to AD, but instead reflect a common phenomenon in dementing diseases(7). Other studin the assessed plasma DHEA and DHEAS levels in AD sufferers (n=72) and compared them to age-matched controls (n=72) showed that Plasma DHEA
concentrations were significantly lower in AD patients compared to
control (4.24+/-0.4 ng/ml for AD; 3.38+/-0.3 ng/ml for control, p=0.027,
Mann-Whitney 1-tailed) and DHEA
levels were significantly correlated to DHEAS levels in both control
and AD conditions (Spearman's rho correlation coefficient=0.635 in
controls and 0.467 in AD, p<or=0.01)(8).
5. Sex-hormone binding globulin
There are evidence in the literature suggests that gonadotropins
may be involved in processes that contribute to the
etiology/pathogenesis of AD such as inflammation, cholesterol
homeostasis, and insulin status. Here we examine the potential
mechanisms by which gonadotropins could influence neurodegenerative processes.(9)
6. Luteinizing hormone (LH)
Some researchers suspected that that another hormone of the
hypothalamic-pituitary-gonadal axis, luteinizing hormone (LH), as a
major factor in AD pathogenesis. In cell
culture, LH increases amyloidogenic processing of amyloid-beta protein
precursor, and in animal models of AD, pharmacologic suppression of LH
and FSH reduces plaque formation. Given the evidence supporting a pathogenic role for LH in AD, a trial of leuprolide acetate, which suppresses LH release, has been initiated in patients.(10)
7. Etc.
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Sources
(1) http://www.pathmed.com/faq/?p=409
(2) http://www.ncbi.nlm.nih.gov/pubmed/18537700
(3) http://www.ncbi.nlm.nih.gov/pubmed/15094079
(4) http://www.ncbi.nlm.nih.gov/pubmed/20840280
(5) http://www.ncbi.nlm.nih.gov/pubmed/9566385
(6) http://www.ncbi.nlm.nih.gov/pubmed/14624021
(7) http://www.ncbi.nlm.nih.gov/pubmed/8732462
(8) http://www.ncbi.nlm.nih.gov/pubmed/19665809
(9) http://www.ncbi.nlm.nih.gov/pubmed/16785601
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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