Wednesday, 1 April 2020

Omega 3 Fatty Acids Decrease the Risk of Non-Alcoholic Fatty Liver Diseases

By Kyle J. Norton

Non-alcoholic Fatty Liver Disease is a condition of fatty liver diseases as a result of accumulated fat in the liver, not caused by abusive alcohol consumption.

Nonalcoholic fatty liver disease (NAFLD) is emerging as a widespread condition in the US, approximately 30% of the adult population are obese.

The disease is also manifested by steatosis, steatohepatitis, cirrhosis.

Obesity is associated linearly to the prevalent risk of nonalcoholic fatty liver disease (NAFLD).

The disease, in most cases, is asymptomatic, however, it has been seen to slowly progress to end-stage liver disease.

According to the statistics, the non-alcoholic fatty liver disease affects over 25% of the US population.

Epidemiological studies suggested that most cases of nonalcoholic fatty liver disease are found in obese and extremely overweight adults. However, people with diabetes, high cholesterol or high triglycerides are associated with the increased risk of the diseases. Truly, 75% of obese have steatosis and 20% to 35% have nonalcoholic steatohepatitis (NASH).

As of today, there is no effective treatment in patients with NAFLD, change of diet and lifestyle to induce weight loss are the most common nonmedical treatment conventionally for management of the disease.

Some researchers suggested that the cause of NAFLD may be associated with the promotion of the Western diet over the past few decades.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of liver diseases, researchers examined the therapeutic benefit of omega-3 polyunsaturated fatty acids (ω-3 PUFAs) on the nonalcoholic fatty liver disease (NAFLD).

The pooled; meta-analyses were conducted using random-effect or fixed-effect models based on the search of databases of PubMed, Cochrane Library, Springer Link, China National Knowledge Infrastructure (CNKI), Wanfang, and Chinese Scientific and Technological Journal (VIP) databases for RCTs on oral ω-3 PUFA supplementation in patients with NAFLD.

According to the results of 18 studies involving 1424 patients, * ω-3 PUFAs exerted a significant benefit for liver fat, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, the liver stress markers, triglycerides, insulin resistance, and glucose, compared to control.

* However, there was significant interstudy heterogeneity.

* Furthermore, subgroup and regression analyses showed no significantly clear methodologic discrepancy. and publication bias and serious adverse events were not detected.

Collectively, researchers said, "Our meta-analysis suggests that ω-3 PUFA supplementation may decrease liver fat and hepatic enzyme parameters".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of non-alcoholic fatty liver diseases, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Omega-3 polyunsaturated fatty acid supplementation and non-alcoholic fatty liver disease: A meta-analysis of randomized controlled trials by Yan JH1, Guan BJ2, Gao HY1, Peng XE. (PubMed)

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