Monday, 20 April 2020

Dandelion(Taraxacum officinale), the Potent Antioxidant Remedy

By Kyle J. Norton

Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.

In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid and cell damage.

There are 3 main types of antioxidants found in nature, including
* Antioxidant enzymes produced by the host, including superoxide dismutase (SOD), glutathione peroxidase, glutathione reductase, and catalases.

* Antioxidants vitamins, that may be injected from the dietary sources such as fruits and vegetables, including vitamins A, C, D, and E. Most antioxidant vitamins are considered free radical scavengers that gobble up free radicals before they can induce a cascade of damage.

* Antioxidant Phytochemicals found in the plant including second metabolites.

Antioxidants keep our bodies functioning properly by reducing the risk of diseases associated with oxidative stress.

Free radicals are highly reactive molecules with an unpaired electron on the outer ring of the atom.
Due to its nature to become stable, free radicals readily to donate or steal an electron from other molecules, leading to the chain of domino's effect that can not be stopped until either the electrons are paired or inhibited by antioxidants.

This chain of reaction is the cause of oxidative stress, a condition is associated with either overexpression of free radicals or depletion of antioxidant enzymes produced by the host organs.

Overexpression of free radicals is known to cause damage in contributing to the etiology of many chronic health problems such as cardiovascular and inflammatory disease, cataracts, and cancer.

Antioxidants, on the other hand, are stable molecules with a unique function in the inhibition of oxidation.


Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of diseases involved in oxidative stress, scientists examined the n-hexane soluble compounds from aerial parts of dandelion (Taraxacum officinale Weber ex F.H. Wigg) antioxidant activity.

Where the n-hexane soluble and insoluble fraction showed a strong antioxidant property such as decreasing the mortality rate caused by degenerative and infectious diseases with an IC50 value of 78 µg/ml and 34 µg/ml, according to the study by the Universitas Gadjah Mada, Yogyakarta.

In chemical analysis, n-hexane (unpolar) fraction showed the presence of 30 biologically active compounds. Phytol [14.7% of total ion current (TIC)], lupeol (14.5% of TIC), taraxasteryl acetate (11.4% of TIC), β-sitosterol (10.3% of TIC), α-amyrin (9.0% of TIC), β-amyrin (8.3% of TIC), and cycloartenol acetate (5.8% of TIC).

In other words, all chemical compounds found in n- (unpolar) fraction work synergistically to protect the cells against alternation induced by overexpression of free radicals.

Moreover, the unipolar fraction exhibited an antioxidant activity comparable to those of 46.7 mmol Trolox equivalents/g extract (determined by 1,1-diphenyl-2-picrylhydrazyl method).

According to the tested differentiation, in vitro, compared to control values obtained from cells infected without treatment, treatment of dandelion showed a low level of HIV-1 replication.

Furthermore, the treatment of dandelion also exerted a strong effect on the viral transcriptase activity in a dose-dependent manner.

In other words, the dandelion extract has potent inhibitory activity against HIV-1 replication and reverse transcriptase activity to induce infection.

Based on the results, researchers suggest, "This fraction demonstrated insignificant antimicrobial activity and can be used in cosmetic and pharmaceutical industries".


Taken altogether, Dandelion may be considered an antioxidant remedy for the protection oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) GC-MS characterization of n-hexane soluble fraction from dandelion (Taraxacum officinale Weber ex F.H. Wigg.) aerial parts and its antioxidant and antimicrobial properties by Ivanov I1, Petkova N1, Tumbarski J2, Dincheva I3, Badjakov I3, Denev P1, Pavlov A. (PubMed)
(2) Antioxidant Activities of n-Hexane Soluble and Insoluble Fraction, Ethyl Acetate Soluble and Insoluble Fraction from Ethanol Extract of Sambung Nyawa Leaf (Gynura procumbens (Lour.) Merr.) by Purwantiningsih Purwantiningsih, Retno Murwanti, and Lukman Hakim, (Research Gate)

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