Monday, 13 April 2020

Herbal Angelica Inhibits the Onset of Male Infertility

By Kyle J. Norton

Infertility is a condition of the inability of a couple to conceive after 12 months of unprotected sexual intercourse.

The condition affects over 5 million couples alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seek help from a professional specialist.

Infertility is very common in the US, approximately 10% of women or 6.1 million, ages 15-44 have difficulty getting pregnant or staying pregnant, according to the Centers for Disease Control and Prevention (CDC).

Male infertility refers to a male's inability to cause pregnancy in a fertile female, accounting for  40–50% of infertility.

The condition affects approximately 7% of all men. 

The most common causes of male infertility are deficiencies in the semen, and semen quality.

In men, age, pesticide and chemical exposure, drug use, radiation, pollution, cigarette or marijuana smoke, heavy alcohol consumption may be some risk factors for the onset of infertility.

In fact, some unfertilized women and men sometimes ago are fertile. However, here are some reasons that have found to increase the risk of infertility in the Western world, including
* Persuade a personal career, before having children.

*Try to be financial stability before having children.

* Too young to be a parent, raising a child needs efforts, time and money.

* Enjoy the couple childless years before committing.

Some researchers suggested that the widespread obesity in North America may be the major factor correlated to the increased infertile rate over the past few decades.

On finding a natural ingredient for the prevention and treatment of infertility, scientists examined the effects of decursin extracted from Angelica Gigas Nakai on antioxidant activity in vitro and in a cryptorchidism-induced infertility rat model.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of the differentiation of rats treated either by distilled water or AG 400 mg/kg of A. gigas extract after 1, 2, and 4 weeks, treatment group with A. gigas extract
* Protected TM3 cells against oxidative stress in a dose-dependent manner,

* Improved the mean weight of the cryptorchid testis,

* Maintained sperm counts, motility, and spermatogenic cell density,

* Decreased levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and increased levels of superoxide dismutase (SOD),

* Significantly increased Nrf2 and heme oxygenase-1 (HO-1), and

* Significantly decreased apoptosis.

These results suggested, "decursin extracted from A. gigas is a supplemental agent that can reduce oxidative stress by Nrf2-mediated upregulation of HO-1 in rat experimentally induced unilateral cryptorchidism and may improve cryptorchidism-induced infertility".

Taken altogether, herbal angelica may be considered an antioxidant remedy for the treatment of oxidative induction of male infertility, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway by Woong Jin Bae, U. Syn Ha, [...], and Sae Woong Kim. (PMC)

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