Tuesday 21 April 2020

Fermented Soy Reduces the Post Ishcmeic Stroke Damage

By Kyle J. Norton

Stroke is a medical condition caused by reduced blood flow to the brain, leading to the death of brain cells due to lack of oxygen or bleeding.

In other words, a stroke can either be results of a blocked artery (ischemic stroke) or the leaking or bursting of a blood vessel (hemorrhagic stroke).

A mini-stroke is a temporary disruption of blood flow to the brain that only causes some disruption to the brain by inducing some minor permanent damage.

Depending on the parts of the neuron being damage, patients may experience different symptoms. However, most common symptoms of stroke include paralysis or numbness of the face, arm or leg, problems in vision, speaking, walking and persistent headache.

Certain medical conditions such as diabetes. heart diseases, long-term use of tobacco, the increase in age, ethnicity are some prevalent risk factors of stroke.

In the US, between 700,000 to 750,000 yearly have a stroke, approximately 1/4 of all stroke victims die as a direct result of the stroke or its complications.

The ischemic stroke is caused by too little blood in the brain when the arteries to your brain are narrowed or blocked, causing severely reduced blood flow (ischemia). 

This deprives your brain cells of oxygen and nutrients, and cells may begin to die within minutes. The most common ischemic strokes are:
* Thrombotic stroke is also sometimes referred to as large-artery strokes. The process leading to thrombotic stroke is complex and occurs over time.

* An embolic stroke occurs when a blood clot or other particle forms in a blood vessel away from your brain. It is usually caused by a dislodged blood clot that has traveled through the blood vessels until it becomes wedged in an artery.

Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.


On finding a potential plant that processes post-stroke activity researchers examined the effect of  Chungkookjang, a traditional Korean fermented soybean food (fermentation Microbes 100730 and 100731 strains of Bacillus amyloliquefaciens(SRCM100730; CKJ730) and SRCM100731(CKJ731)) protected against ischemic stroke and post-stroke hyperglycemia in Mongolian gerbils with ischemic stroke induced by transient occlusion of the carotid arteries.

According to the results of the analysis of gerbil fed 4.5% cooked soybeans (CSB), CKJ730, CKJ731, or cellulose (negative-control) in 40 energy% fat diets for 3 weeks, and then had artery occlusion for 8 min and continued taking the assigned diet for 5 weeks.
* CKJ730 and CKJ731 had thrombolytic activity and prevented neuronal cell death and improved short-term memory and spontaneous alteration compared to the negative control.

* CKJ730 and CKJ731 improved neurological symptoms including drooped eyes, crouched posture, flexor reflex, and walking patterns the most among the stroke-induced gerbils. CKJ730 and CKJ731 increased active time, grip strength, and blood flow measured by Doppler compared to the negative control. 

* CKJ730 protected against post-stroke glucose dysregulation by restoring β-cell mass in the gerbils with transient artery occlusion.

* Serum tumor necrosis factor-α and interleukin-1β levels associated with inflammatory cytokines were lower in CKJ730 and CKJ731 than the negative control.

* CSB also improved glucose metabolism and suppressed inflammatory cytokines, but less than CKJ730 and CKJ731.

* CKJ730 and CKJ731 changed the amounts of Bacteriodia and Clostridia to be similar to normal control.


Collectively, researchers said, " the daily intake of chungkookjang fermented with B. amyloliquefaciens improved the gut microbiome, increased blood flow to the brain, suppressed systemic inflammation, and may reduce the susceptibility to injury from ischemic stroke in gerbils subjected to ischemic injury".

Taken altogether, fermented Soy may be considered a functional food for the treatment of ischemic stroke injury, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chungkookjang, a soy food, fermented with Bacillus amyloliquefaciens protects gerbils against ischemic stroke injury, and post-stroke hyperglycemia by Jeong DY1, Jeong SY1, Zhang T2, Wu X2, Qiu JY2, Park S. (PubMed)

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