Wednesday 22 April 2020

Herbal Angelica Reduces Myocardial Infarction Damage

By Kyle J. Norton

Myocardial infarction is a severe and medical emergency characterized by the obstruction of the blood supply to the brain, causing a stroke. Prompt treatment can minimize brain damage and potential post disease complications.

The occurrence and extent of brain infarction are associated with three basic factors, including the site of arterial occlusion, the rapidity of arterial occlusion, and the presence or absence of collateral circulation.

In other words, brain infarction can be classified into myocardial infarction due to plaque rupture and myocardial oxygen supply-demand imbalance secondary to other acute illnesses.

Stroke is caused by the accumulation of plaques or blood clots that build up the arterial walls.  In other words, if plaques or blood clots building up in the arteries is blocking the circulation of blood in any part of the body causing oxygen not to be delivered to the brain, leading to the death of some cells in the brain.

According to the statistics, every year, more than 790,000 people suffer a stroke, including 600,000 of these are first attacks, and 185,000 are recurrent attacks. Most cases of stroke occur in people over the age of 65.

The exact causes of a blood clot to induce acute brain infarction are unknown. Plaques accumulation in the arteries associated with hardening and stiffing arterial walls is a leading cause of cardiovascular disease, including stroke.

The trouble with speaking and understanding, confusion, sudden numbness, weakness or paralysis in your face, arm or leg, headache and the trouble with walking are some of the most common symptoms found in patients with post-myocardial infarction.

Depending on the severity of the acute infarction, in serious cases, patients may also experience symptoms, paralysis of the face, arm or leg, trouble with seeing in one or both eyes.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a chemical ingredient for the management of post-stroke researchers examined the mechanisms of Angelica Sinensis and Angelica sinensis polysaccharide (ASP for the treatment of acute myocardial infarction (AMI).

According to the results of the analysis, A. Sinensis exerted effect on.228 major targets that regulate multiple pathways in multiple targets involved in several biological processes against AMI injury.

In vitro and in vivo, ASP significantly decreased endoplasmic reticulum (ER) stress-induced cell death both in ischemia injury rats.

Furthermore, ASP treatment reduced infarct size and preserved heart function.

ASP enhanced activating transcription factor 6 (ATF6) activity in restoring the ER function in stressed cells.

Most importantly, ASP attenuated levels of proinflammatory cytokines and maintained a balance in the oxidant/antioxidant levels against the onset of oxidative stress after AMI.

Taken altogether, Herbal Angelica may be used for the treatment of myocardial infarction, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Network pharmacology-based identification of major components of Angelicasinensis and its action mechanism for the treatment of acute myocardial infarction by Niu X1,2, Zhang J2,3, Ni J4, Wang R1,2, Zhang W5, Sun S5, Peng Y2,6, Bai M2,6, Zhang Z. (PubMed)

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