Saturday, 18 April 2020

Fermented Soy Processes Anti Inflammatory Cytokines Release

By Kyle J. Norton

Inflammation is a natural immune response involving the stimulated production of pro-inflammatory activity with a target to protect our body against foreign invasions such as virus and bacteria after injury and damage.

In the acute phase of infection, the immune white blood cells in the first line of defense stimulating the blood vessel constriction and palette accumulated to the injury area to cover the wound and the proteins associated with the production of the pro-inflammatory cytokines to kill off the invasive microorganisms.

In people with a strong immune system, during the acute phase of infection, the levels of pro-inflammatory cytokines are balanced by the expression of anti-inflammatory cytokines without affecting the immune activity.

However, in children, the elderly and people with the weakened immune system, overexpression of proinflammatory cytokines can damage the nearby cells and tissue, leading to the formation of scars.

Chronic inflammation is a medical disease caused by the immune inability to destroy the invaders in the acute phase of infection, leading to the immune system in the adaption of the change.

Over time, chronic inflammation can have a strongly negative impact on the affected tissues and organs.

In other words, pro-inflammatory cytokines are activated through systematic immune response to the damage cells which release chemicals including histamine, bradykinin, and prostaglandins to protect the injure area or location against infection, leading to blood vessels to leak fluid into the tissues, causing swelling and other symptoms such as pain, swelling, and redness.

However, in most cases, over-response of the immune system can lead to over expressions of certain pro-inflammatory cytokines, depending on the injured location such as Interleukin (IL)-1 and tumor necrosis factor (TNF) which can lead shock and death of healthy cells in the infectious location.

In most cases, long-term overexpression of pro-inflammatory cytokines can lead to chronic inflammatory disease as the immune system no longer can kill the invasive agents and heal the damage caused by acute infection.

Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.


On finding a potential plant that processes anti-inflammatory activity researchers examined the effect of health benefits of QCAN® Plus-an easily available fermented soy drink.

The study included lean (n = 10) and obese (n = 10) subjects, during pre-soy (weeks -2, -1, and 0), on-soy (weeks 1, 2, 3, and 4), and post-soy (weeks 6, 8, 10, and 12) periods.

According to the results of the analysis,
* The lipid peroxidation associated with total cholesterol and low-density lipoprotein (LDL) cholesterol levels were significantly reduced in both lean and obese individuals during on-fermented soy treatment.

* Cytokines associated with inflammation such as platelet-derived growth factor (PDGF) AA and AB/BB were significantly lowered on-soy compared with pre-soy (P ≤ .05) in lean subjects.

* PDGF AA, IL-1RA, and GMCSF associated with insulin resistance, lipoperoxidation and inflammation were significantly reduced on-soy (P ≤ .05) in obese subjects, respectively.

* Q-CAN Plus was safe.
Collectively, researchers said, "Q-CAN Plus ensures its safety for consumption and highlights its hypolipidemic and suppressive effect on certain cytokines".

Taken altogether,  QCAN®  may be considered a functional food for the prevention of the initiation of cytokines, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Fermented Soy Beverage Q-CAN Plus Consumption Improves Serum Cholesterol and Cytokines by Arumugam S1, Dioletis E1, Paiva R1, Fields MR2, Weiss TR2, Secor ER3, Ali A, (PubMed)

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