Devil's Club Shows a Strong Anticancer Activities in Vitro and Vivo

By Kyle J. Norton

Cancer is the class of diseases associated with the growth of the cells disorderly and uncontrollably due to the alternation of DNA.

Most cases of cancer begin in the cells on the surface of the inner lining tissues of the organ or gland. At the early stage, most cancers are asymptomatic.

However, at the advanced stage, most cancers not can induce common symptoms such as gastrointestinal discomforts, unintended weight loss, loss of appetite and fatigue but also localized symptoms depending on the affected tissues and organs.

Cancers at this stage also can travel a distance away from the original site to induce secondary metastasis.

According to the statistics provided by the American cancer society, in 2018,1,735,350 new cases were diagnosed, representing more than 4,700 new cancer diagnoses each day.

The lifetime probability of being diagnosed with cancer is 39.7% for men and 37.6% for women.

Cancers are the second leading cause of death worldwide besides heart diseases.

The most common types of cancer in Canada include lung, colorectal, breast and prostate cancers. And these 4 cancers are account for half of all cancers diagnosed in Canada.

Believe or not, 1/4 of cancers death are due to lung cancer.

Depending on types of cancer, people with cancers may experience general and specific symptoms.
Compared to all cancers, lung, breast, prostate, and colorectal cancers are the most common cancer in the US.

Most invasive cancers process angiogenetic ability by which they can divide and spread.

 Angiogenesis is the process that develops new blood vessels from pre-existing vessels by invasive tumors to provide energy(nutrition and fluids) for cancerous cells growth and proliferation. 

Devil's Club is a large shrub, genus Oplopanax, belonging to the family Aralioideae, native to the cool moist forests of western North America. 

The herb has been used in traditional and herbal medicine as Adaptogen, Antipyretic, Pain Reliever, Antitussive, Antibacterial agent and to treat Arthritis, Diabetes, Colds, Cough, Sore throat, Chest congestion, Stomach pain, Constipation, Gall stones, Influenza, Cancer, etc.

On finding a potential compound for the treatment of chronic diseases, scientists examined the anticancer effects of O. horridus (Devil's club).

* The different extracts from Oplopanax root, stem, berry, root bark, and their fractions were investigated in vitro for their potential antiproliferative effects on human HCT-116, HT-29, and SW-480 colorectal cancer cell lines [19–21, 47].

* Male and female transgenic C57BL/6J-Foxp3-RFP mice (C57BL/6- Foxp3tm1Flv/J) were employed for in vivo anti-AML. After one week following engraftment, the 70% ethanol extract of Oplopanax root was diluted into the drinking water at a final concentration of 20 g/mL. The survival of both male and female mice were significantly increased upon the inclusion of the extract in the drinking water [45].

*  The effects of the extracts and polyynes have also been evaluated using MCF-7 and MDA-MB-231 human breast cancer cell lines [19, 21, 47]. The IC50 of the total extract, 50, 70, and 100% ethanol fractions on MCF-7 cells were 248.4, 123.1, 44.0, and 31.5 g/mL, respectively [47].

* The antiproliferative effects of nonsmall cell lung cancer (NSCLC) cells were evaluated. The IC50 of the extract, 50, 70, and 100% ethanol fractions for antiproliferation on NSCLC cells, were 125.3, 271.1, 17.6, and 23.2g/mL, respectively [19].

* The extract significantly inhibited the proliferation of HP62 at low IC50. Apoptosis focused antibody array profile indicated upregulation of cytochrome C, claspin, cIAP-2, and HTRA2/Omi apoptosis-related markers, suggesting that the effect was via targeting the intrinsic mitochondrial apoptosis pathway [51]

Taken altogether, Devil's Club may be considered an anticancer remedy,, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Oplopanax horridus: Phytochemistry and Pharmacological Diversity and Structure-Activity Relationship on Anticancer Effects by Wu K1, Wang CZ2, Yuan CS2, Huang WH. (PubMed)