Friday 24 April 2020

Elecampane (Inula helenium) Destroys Lung Cancer Cells in Vitro

By Kyle J. Norton

The lung is a vital organ of the human being, located near the backbone on either side of the heart with functions of inhaling oxygen from the air then transporting them to the bloodstream to nourish the body cells' need and exhaling carbon dioxide from the bloodstream.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. The most common forms of primary lung cancers are derived from epithelial cells.


The most common form of primary lung cancers is derived from epithelial cells.

The exact cause of lung cancer is not identified. However, epidemiologically, smoking, second smoke, exposure to certain chemicals, family history, people who have lung disease and excessive drinking are some prevalent factors associated with lung cancer developing.

According to the statistics provided by the American cancer society, Lung cancer accounts for 14% of all new cancers diagnosed in the US. In 2018, there were about 234,030 new cases of lung cancer (121,680 in men and 112,350 in women). Lung cancer also causes the death of 83,550 in men and 70,500 in women in the same year.

Lung cancer can be classified into 2 major types
* Non-small cell lung cancer is the most common type of lung cancer that usually grows and spreads methodically and predictably.

* Small cell lung cancer is a fast-growing type of lung cancer, that can spread to distant parts of the body in a relatively early stage.


On finding a natural ingredient for the prevention and treatment of lung diseases, scientists examined the anti-lung cancer effects of Alantolactone (ALT), a sesquiterpene lactone compound isolated from Inula helenium.

Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia. 

The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to tested analysis,
* ALT inhibited cell growth and induced S‑phase arrest and cell apoptosis in A549 and NCI‑H520 cells.

* ALT increased the level of ROS, inhibited the Akt/glycogen synthase kinase (GSK)3β pathway and induced endoplasmic reticulum (ER) stress to prevent proliferation and cause apoptosis of A549 and NCI‑H520 cells.

* Most importantly, ALT treatment sensitized lung cancer cells to Gemcitabine (GEM) by enhancing the chemo drug efficacy.

Based on the results, researchers suggest, "combined treatment with ALT and GEM may have potential as a clinical strategy for lung cancer treatment".

Taken altogether, Dandelion may be considered a remedy for the treatment of lung cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Alantolactone enhances gemcitabine sensitivity of lung cancer cells through the reactive oxygen species-mediated endoplasmic reticulum stress and Akt/GSK3β pathway by Wang J1, Zhang Y1, Liu X2, Wang J2, Li B3, Liu Y3, Wang J. (PubMed)

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