Wednesday 22 April 2020

Dandelion(Taraxacum officinale) Process Anti-Pulmonary Fibrotic Activity in Vitro and Vivo

By Kyle J. Norton

The lung formed part of the respiratory system with a function of the primary organs of the respiratory system to absorb oxygen to the blood and exhale carbon dioxide from the blood.

Lung diseases are medical conditions, that affect the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing.

People with lung diseases have breathing problems, that prevent them to get enough oxygen for the body's needs.

According to the statistic from the World Health Organization, respiratory diseases are leading causes of death and disability in the world. chronic obstructive pulmonary disease (COPD) and asthma are 2 of the most common respiratory disease, affecting 65 million and 334 million people, respectively.

3 million people die from chronic obstructive pulmonary disease (COPD) each year, making it the third leading cause of death worldwide. And 14% of 334 million people suffer from asthma are children.

Long-term smoking is considered one of the leading risk factors of lung diseases. Other risk factors associated with the onset of lung diseases include radon, asbestos, second-hand smoke, and air pollution.

Pulmonary fibrosis (PF) is a condition that the lung tissue becomes damaged and scarred. The damage that causes thickened, stiff tissue makes the lung more difficult to perform its function abnormally.

More precisely, pulmonary fibrosis (PF) is a chronic and progressive condition of lung disease characterized by reduced numbers and increased stiffness of air sac in the lungs (alveoli), affecting the lung breathing function to provide enough oxygen into the bloodstream.

According to the American Lung Association, the most common PF is idiopathic pulmonary fibrosis. Approximately 50,000 new cases of IPF are diagnosed each year.

The most common symptoms of PF are shortness of breath, dry, and hacking cough, fast, and shallow breathing, tiredness, aching joints, and muscles and clubbing of the tips of the fingers or toes.

Most cases of IPF are found in patients between the ages of 50 and 70 years old, particularly in men.

Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.

On finding a natural ingredient for the prevention and treatment of lung diseases, scientists examined the Chinese herbals decoctions, including Pu Gong Ying on PF.

The formula showed to effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo.

The efficacy of the decoct is associated with over one hundred oil-soluble chemicals found in lipid extracts from other Chinese herbals decoctions that work synergistically against the damage in the lung tissues.

More precisely, the active component in the decoction is two forms of phosphocholines, PC (18:0/18:2) and PC (16:0/18:2) could form liposomes with small RNAs to enter human alveolar.

Taken altogether, Dandelion may be considered a remedy for the treatment of PF, pending to the confirmation of the larger sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonaryfibrotic HJT-sRNA-m7 by Du J1, Liang Z1, Xu J1, Zhao Y1, Li X1, Zhang Y1, Zhao D1, Chen R1,2, Liu Y3, Joshi T3,4, Chang J1, Wang Z1, Zhang Y1, Zhu J1, Liu Q1, Xu D3, Jiang C. (PubMed)

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