Thursday, 23 April 2020

Fermented Soy Improves Brain Blood Flow in Post-Stroke Hyperglycemia in Vivo

By Kyle J. Norton

Stroke is a medical condition in which the brain function is interrupted rapidly due to the loss of blood supply caused by the blockage of blood such as thrombosis and arterial embolism, or leakage of blood that lead to the death of brain cells.

Stroke is a condition associated with the plagues build-up in the arteries and high blood pressure. 

In other words, if plagues building up in the arteries is blocking the circulation of blood in any part of the brain, causing oxygen not to be delivered to the brain, resulting in some cells in the brain to die off and are unable reproduce,

Besides cancer and heart diseases, stroke is the third leading cause of death. Approximately 1/4 of all stroke victims die as a direct result of the stroke or its complications.

According to the statistics of the Heart and Stroke Foundation, strokes kill 45% more women than men in Canada.

There are 2 types of stroke
* Ischemic stroke is the most common type of stroke accounting for almost 80% of all strokes.

* Hemorrhagic stroke occurs when a blood vessel bursts inside the brain, causing an increase of the fluid pressure on the brain and harms the brain by pressing it against the skull.

Hyperglycemia, a medical condition of abnormally high blood glucose, is a major concern, in people with both type 1 and type 2 diabetes.

Most cases of hyperglycemia occurred in patients who do not manage their diabetes properly.

Untreated hyperglycemia has been found to induce ketoacidosis characterized by the symptoms shortness of breath, breath that smells fruity and gastrointestinal discomforts such as nausea, vomiting, and dry mouth.

The post-stroke hyperglycemia management is the interventions associated with the management of physiological variables such as blood glucose, blood pressure, hypoxia, hydration, and temperature


Fermented soy products are diverse varieties of soy food that are made from fermented soybeans, including miso, natto, tempeh, and soy sauce.


On finding a potential plant for the neuroprotection after stroke, researchers examined the effect of chungkookjang made with Sunchang Research Center for Fermentation Microbes 100730 and 100731 strains of Bacillus amyloliquefaciens(SRCM100730; CKJ730) and SRCM100731(CKJ731) on post-stroke hyperglycemia in Mongolian gerbils.

Where the Gerbil which either was fed 4.5% cooked soybeans (CSB), CKJ730, CKJ731, or cellulose (negative-control) in 40 energy% fat diets for 3 weeks, and then had artery occlusion for 8 min and continued taking the assigned diet for 5 weeks.

According to the results of the analysis,
* CKJ730 and CKJ731 had thrombolytic activity and prevented neuronal cell death.

* CKJ730 protected against post-stroke glucose dysregulation by restoring β-cell mass in the gerbils with transient artery occlusion.

* Serum tumor necrosis factor-α and interleukin-1β levels were lower in CKJ730 and CKJ731 than the negative control.

* CSB also improved glucose metabolism and suppressed inflammatory cytokines, but less than CKJ730 and CKJ731.

* Clostridia increased, and Bacteriodia slightly decreased in the negative-control group, compared to the normal control.

Collectively, researchers said, "the daily intake of chungkookjang fermented with B. amyloliquefaciens improved the gut microbiome, increased blood flow to the brain, suppressed systemic inflammation".

Taken altogether, potato may be considered a functional food for the prevention and treatment of post-stroke hyperglycemia-induced complications,, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Chungkookjang, a soy food, fermented with Bacillus amyloliquefaciens protects gerbils against ishcmeic stroke injury, and post-stroke hyperglycemia by Jeong DY1, Jeong SY1, Zhang T2, Wu X2, Qiu JY2, Park S. (PubMed)

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