Monday, 11 May 2020

Topical Elecampane Inhibits the Onset of Atopic Dermatitis

By Kyle J. Norton

Dermatitis or eczema is a group of diseases characterized by the inflammation of the skin.

There is no single cause of eczema, anything that we face every day can trigger a dermatitis flare, including stress, irritants, climate change, and sweating. However, infection and allergens.are considered the most common causes of the disease.
Atopic dermatitis or eczema is an inflammatory condition associated with red and itchy skin.

Most cases of atopic dermatitis are found in children. However, adults may also get it too. Skin irritation is found more often in children compared to adults.

The causes of atopic dermatitis are unknown. Some researchers suggested that certain risk factors such as genetic preposition and abnormal function of the immune system and environment conditions may be involved in the development of the disease.

Epidemiological studies suggested that most patients with chronic atopic dermatitis also have asthma and hay fever, particularly in allergies.

Children are at a higher risk of atopic dermatitis compared to adults.

Most cases of atopic dermatitis are healed by itself or by rehydrating the skin with topical forms of petroleum jelly, such as Vaseline.

However, in serious cases, topical steroids to reduce inflammation and control itching may be prescribed. In patients with itching scratch, oral antihistamines may be recommended.

Besides red patches and itching on the affected area, patients may also experience symptoms of dry skin, small bumps containing fluids, cracked and scaly, sensitive, swollen skin due to scratching.

On finding a natural ingredient for the prevention and treatment of skin diseases, scientists examined the total sesquiterpene lactones isolated from Inula helenium L. (TSL-IHL) effect on atopic dermatitis (AD).
Elecampane, also known as Horse-heal (Inula helenium) is a perennial composite plant, genus nulla, belonging to Asteraceae, native to Southern Europe, and Asia. 

The plant has been used in traditional and herbal medicine in treating bronchitis or emphysema, night sweats, pulmonary tuberculosis, irritating cough, catarrhal discharges, etc.

According to tested analysis,
* TSL-IHL, as well as AL and IAL, inhibited the proteins TNF-α-induced activation of pro-inflammatory cytokines NF-κB and the expression of TNF-α, IL-1, and IL-4 in HaCat cells in a dose-dependent manner in the range of 0.6-2.4 µg/ml.

* The topical application of TSL-IHL (1% W/W in emollient cream) attenuated DNCB-induced dermatitis severity and right ear swelling.

* Additionally, the serum levels of IgE produced by the immune system, TNF-α, and IFN-γ involved in the inflammatory phase in TSL-IHL-treated mice were reduced by 81.39%, 89.69%, and 87.85%, respectively.

* Moreover, the mRNA levels of IL-4, IL-5, and IL-13 associated with the inflammatory response in the back-skin lesions of TSL-IHL-treated mice were reduced by 39.21%, 40.62%, and 48.12%, respectively, compared to the untreated controls.

More precisely, TSL-IHL treatment reduced epidermis/dermis thickening and dermal inflammatory infiltration in both ear and back skins.

Based on the results, researchers suggest, "TSL-IHL inhibited the development of AD-like skin symptoms by regulating cytokine expression and may be an effective alternative therapy for AD".

Taken altogether, Dandelion may be considered a remedy for the treatment of atopic dermatitis, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Total sesquiterpene lactones isolated from Inula helenium L. attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice by Wang Q1, Gao S2, Wu GZ2, Yang N2, Zu XP2, Li WC2, Xie N3, Zhang RR4, Li CW5, Hu ZL2, Zhang WD. (PubMed)

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