Friday 8 May 2020

Pinto Bean (Phaseolus) Suppresses the Onset of Nasopharyngeal Cancer in Vitro

By Kyle J. Norton

The nasopharynx is the upper part of the pharynx, connecting with the nasal cavity above the soft palate that allows a person to breathe through the nose.

Cancer is a group of diseases caused by cell growth irregularly in the affected tissue caused by DNA alternation.

Nasopharyngeal cancer is a medical condition characterized by cells growth irregularly and disorderly in the tissues of the nasopharynx.

Most cases of nasopharyngeal cancer start in the cells on the surface of the inner lining of the nasopharynx. The early stage of nasopharyngeal cancer is asymptomatic due to the very small size of the tumor.

However, at the advanced stage, the oversize may suppress the nearby nerves and blood vessels, leading to severe throat pain and symptoms of a lump in your neck blood in the saliva, bloody discharged from your nose, particularly, persistent nasal congestion or ringing in your ears, accompanied with the general symptoms shared with other cancers.

According to the statistics provided by the American cancer society, nasopharyngeal cancer (NPC) is quite rare in the United States). The risk of cancer is less than one case for every 100,000 people.
Epidemiologically, some patients at this stage may also experience symptoms of frequent ear infections, hearing loss and headaches.

Pharynx cancer is originated in the tissue of the pharynx and classified
* The nasopharynx (the upper part of the throat behind the nose)
Cancer of the pharyngeal most commonly begins with malignant cells that line the nasopharynx, including nasal passages and auditory tubes join the remainder of the upper respiratory tract.

* The oropharynx (the middle part of the pharynx)
Cancer of the oropharynx also begins with the malignant cells that line the oropharynx, including the base of the tongue, the tonsils, the soft palate.

* The hypopharynx (the bottom part of the pharynx)
Cancer of the hypopharynx most commonly begins with the malignant squamous cell that lines the hypopharynx where the area of the larynx and esophagus meet. 90% of oropharyngeal neoplasms are squamous cell carcinoma.

On finding a natural ingredient for the prevention and treatment of diseases associated with oxidative stress, scientists examined the effects of purification of a glucosamine-binding antifungal lectin from Phaseolus vulgaris cv. Chinese pinto beans on cancers.


Pinto bean is also known as common bean, genus Phaseolus and the family Fabaceae. It has a mottled appearance of darker reddish-brown spots on a lighter brownish beige background, thus appearing painted or spotted.

According to tested analysis,
* Lectin at 30 μM showed strong antioxidant activity against the infectious agents including fungal species such as Phyllosticta citriasiana, Magnaporthe grisea, Bipolans maydis, Valsa mali, Mycosphaerella arachidicola in the induction of oxidative stress associated with proteins lipids and DNA damage.

* The lectin did not exert any discernible antiproliferative effects on breast cancer MCF-7 cells but was able to suppress proliferation of nasopharyngeal carcinoma HONE-1 cells, with an IC50 of 17.3 μM.

In other words, purification of a glucosamine-binding antifungal lectin from Phaseolus vulgaris cv. Chinese pinto beans exerted a significantly apoptotic activity against the viral induction of nasopharyngeal carcinoma HONE-1 cells.


Taken altogether, Pinto beans may process antioxidant and cytotoxic properties against nasopharyngeal cancer cells, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Purification and characterization of a glucosamine-binding antifungal lectin from Phaseolus vulgaris cv. Chinese pinto beans with antiproliferative activity towards nasopharyngeal carcinoma cells by Ang AS1, Cheung RC, Dan X, Chan YS, Pan W, Ng TB. (PubMed)

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