Monday 4 May 2020

Angelica Sinensis Induces Bladder Cancer Cell Death

By Kyle J. Norton

The bladder is a hollow elastic organ in the center of the lower abdomen that collects urine from the kidneys and excreted them through the urethra.

Bladder cancer is the most common type of cancer that affects men twice as frequently as it affects women.

Usually, cancer starts from the lining of the bladder caused by several types of malignant growths of the urinary bladder cells. However, after growing large enough, the cancerous call can spread to other regions in the body through the circulation of fluids and blood.

According to the statistic. 90% of bladder cancer were diagnosed in people who are older than 55. and the average age of people are diagnosed with bladder cancer is 73.

Every year, the disease causes over 17,000 deaths and bladder cancer is the eighth most common cause of cancer death in men.

According to the statistic, men are 4 times more likely than women to be diagnosed with the disease.

Out of the many causes of bladder cancer, researchers found that lifelong smoking, aging, and chronic bladder inflammation are some of the most common prevalent risk factors of bladder cancer cases found in the Western world.

Bladder cancer can be classified into 2 types,
* Superficial types of bladder cancer
This type of bladder cancers has a characteristic of often recurrence but usually non-invasive. It can be controlled or removed by regular cystoscopy.

*Invasive types of bladder cancer.
Invasive types of bladder cancer tend to spread after beginning in cells in the lining of the bladder. It often requires surgery by removing part or the whole bladder.


On finding a natural ingredient for the prevention and treatment of cancer, scientists examined the anti bladder cancer activity of N-butylidenephthalide (BP) isolated from Radix Angelica Sinensis (Danggui) both in vivo and in vitro.

  Angelica or Dang Gui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to tested analysis,
* The administration of BP caused bladder cancer cell death in a time- and dose-dependent manner and induced apoptosis via the activation of pro-apoptotic proteins caspase-9 and caspase-3.

* Furthermore, BP also suppressed the migration of bladder cancer cells, revealed by the trans-well and wound healing assays.

* In vitro, BP up-regulated the tumor suppressor E-cadherin and down-regulation of N-cadherin involved in cancer metastasis and increase tumor cell proliferation.

* Moreover, BP also suppressed BFTC xenograft tumor growth and caused a 44.2% reduction of tumor volume after treatment for 26 days.

* Most importantly, in combination with BP, the sensitivity of these bladder cancer cells to cisplatin increased significantly.

Based on the results, researchers suggest, "The incidence of bladder cancer decreased in patients who were exposed to Angelica sinensis, suggesting that BP could serve as a potential adjuvant in bladder cancer therapy regimen".

Taken altogether, Angelica may be considered a remedy for the treatment of bladder cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer by Chen MC1, Hsu WL2,3, Chang WL4, Chou TC. (PubMed)
(2) Potential therapeutic effects of N-butylidenephthalide from Radix Angelica Sinensis (Danggui) in human bladder cancer cells by Chiu SC1,2,3, Chiu TL4, Huang SY5, Chang SF1, Chen SP6, Pang CY7,8, Hsieh TF. (PubMed)

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